Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?

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dc.contributor.authorPereira, Tiago Veiga
dc.contributor.authorRudnicki, Martina
dc.contributor.authorPereira, Alexandre Costa
dc.contributor.authorPombo-de-Oliveira, Maria S.
dc.contributor.authorFranco, Rendrik Franca
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Nacl Canc
dc.contributor.institutionFleury Res Inst
dc.date.accessioned2016-01-24T12:41:37Z
dc.date.available2016-01-24T12:41:37Z
dc.date.issued2006-12-01
dc.description.abstractMeta-analysis has become an important statistical tool in genetic association studies, since it may provide more powerful and precise estimates. However, meta-analytic studies are prone to several potential biases not only because the preferential publication of positive'' studies but also due to difficulties in obtaining all relevant information during the study selection process. in this letter, we point out major problems in meta-analysis that may lead to biased conclusions, illustrating an empirical example of two recent meta-analyses on the relation between MTHFR polymorphisms and risk of acute lymphoblastic leukemia that, despite the similarity in statistical methods and period of study selection, provided partially conflicting results.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst Coracao, Dept Biochem & Mol Biol, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Inst Heart, InCor, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Clin & Toxicol Anal Dept, São Paulo, Brazil
dc.description.affiliationInst Nacl Canc, Div Expt Med, Rio de Janeiro, Brazil
dc.description.affiliationFleury Res Inst, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Coracao, Dept Biochem & Mol Biol, BR-05403000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Inst Heart, InCor, BR-05403000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent885-886
dc.identifierhttp://dx.doi.org/10.1007/s10654-006-9079-9
dc.identifier.citationEuropean Journal of Epidemiology. New York: Springer, v. 21, n. 12, p. 885-886, 2006.
dc.identifier.doi10.1007/s10654-006-9079-9
dc.identifier.issn0393-2990
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29279
dc.identifier.wosWOS:000243905100007
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Epidemiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectchildhooden
dc.subjectleukemiaen
dc.subjectmeta-analysisen
dc.subjectMTHFRen
dc.subjectpolymorphismen
dc.titleDo polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?en
dc.typeinfo:eu-repo/semantics/article
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