Specific effects of reactive thiol drugs on mitochondrial bioenergetics

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dc.contributor.authorNantes, Iseli L.
dc.contributor.authorRodrigues, Tiago
dc.contributor.authorCaires, Antonio C. F.
dc.contributor.authorCunha, Rodrigo L. O. R.
dc.contributor.authorPessoto, Felipe S. [UNIFESP]
dc.contributor.authorYokomizo, Cesar H.
dc.contributor.authorAraujo-Chaves, Juliana C.
dc.contributor.authorFaria, Priscila A.
dc.contributor.authorSantana, Debora P.
dc.contributor.authorSantos, Carolina G. dos
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Mogi das Cruzes
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:07Z
dc.date.available2016-01-24T14:06:07Z
dc.date.issued2011-02-01
dc.description.abstractIn this minireview, the more recent findings about the effects of peculiar reactive thiol drugs on mitochondria are presented. These include the following compounds: metallo meso-tetrakis porphyrins, palladacycles, telluranes and phenothiazines. Metallo meso-tetrakis porphyrins can exhibit both beneficial and deleterious effects on mitochodria that are modulated by the central metal, cell location, and availability of axial ligands. Therefore, these compounds have the versatility to be used for cell and mitochondria protection and death. the antioxidant activity of manganese porphyrins is related to a glutathione peroxidase-like activity. By attacking exclusively the membrane protein thiol groups without glutathione depletion, palladacycles are able to induce mitochondrial permeability transition (MPT) and cytochrome c release in the absence of oxidative stress. in hepatoma cells, the mitochondrial action of palladacycles was able to induce apoptotic death. As opposed to palladacycles, telluranes and phenothiazines are able to conjugate the capacity to promote the MPT in a dose-dependent manner in association with efficient antioxidant activity toward lipids. These studies demonstrated that the action of drugs on mitochondrial bioenergetics can be modulated by peculiar reactivity with thiol groups. Therefore, they contribute to studies of toxicity as well as the design of new drugs.en
dc.description.affiliationUniv Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, BR-08780911 Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Mol, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Mol, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent11-18
dc.identifierhttp://dx.doi.org/10.1007/s10863-011-9328-9
dc.identifier.citationJournal of Bioenergetics and Biomembranes. New York: Springer/plenum Publishers, v. 43, n. 1, p. 11-18, 2011.
dc.identifier.doi10.1007/s10863-011-9328-9
dc.identifier.issn0145-479X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33407
dc.identifier.wosWOS:000287970700003
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Bioenergetics and Biomembranes
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectThiol reactivityen
dc.subjectMitochondrial permeability transitionen
dc.subjectPorphyrinsen
dc.subjectPalladacyclesen
dc.subjectTelluranesen
dc.subjectPhenothiazinesen
dc.titleSpecific effects of reactive thiol drugs on mitochondrial bioenergeticsen
dc.typeinfo:eu-repo/semantics/article
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