Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome

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dc.contributor.authorDalla Torre, Cristiane Arruda [UNIFESP]
dc.contributor.authorLee, MLD
dc.contributor.authorYoshimoto, Maysa
dc.contributor.authorLopes, Luis Fernando
dc.contributor.authorMelo, L. N.
dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.authorAndrade, Joyce Anderson Dufles [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T12:33:24Z
dc.date.available2016-01-24T12:33:24Z
dc.date.issued2002-06-01
dc.description.abstractWe report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. the cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at different moments of the disease. One patient showed the Ph chromosome at disease transformation and the other at diagnosis. the different breakpoints at 4q and the presence of Ph could be a marker of this form of MDS. the association of clinical and hematological findings suggests the possibility of a new group of pediatric MDS. (C) 2002 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Morphol, Discipline Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, GRAACC, Inst Oncol Pediat, BR-04023900 São Paulo, Brazil
dc.description.affiliationHosp AC Carmargo Fundacao Antonio Prudente, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Hematol, Botucatu, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Morphol, Discipline Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, GRAACC, Inst Oncol Pediat, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent533-538
dc.identifierhttp://dx.doi.org/10.1016/S0145-2126(01)00152-7
dc.identifier.citationLeukemia Research. Oxford: Pergamon-Elsevier B.V., v. 26, n. 6, p. 533-538, 2002.
dc.identifier.doi10.1016/S0145-2126(01)00152-7
dc.identifier.issn0145-2126
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26885
dc.identifier.wosWOS:000175972700003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLeukemia Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectmyelodysplastic syndromeen
dc.subjectPhiladelphia chromosomeen
dc.subjectchromosome 4en
dc.subjectdeletionen
dc.subjectcytogeneticen
dc.subjectFAB groupen
dc.titleMyelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosomeen
dc.typeinfo:eu-repo/semantics/article
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