The role of the paratrigeminal nucleus in the pressor response to sciatic nerve stimulation in the rat

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dc.contributor.authorCaous, Cristofer André [UNIFESP]
dc.contributor.authorKoepp, Janice
dc.contributor.authorCouture, Rejean
dc.contributor.authorBalan, Antonio Claudir [UNIFESP]
dc.contributor.authorLindsey, Charles Julian [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Israelita Ensino & Pesquisa Albert Einstein
dc.contributor.institutionUniv Montreal
dc.date.accessioned2016-01-24T13:51:26Z
dc.date.available2016-01-24T13:51:26Z
dc.date.issued2008-06-01
dc.description.abstractThe paratrigeminal nucleus (Pa5), an input site for spinal, trigeminal, vagus and glossopharyngeal afferents, is a recognized site for orofacial nociceptive sensory processing. It has efferent connections to brain structures associated with nociception and cardiorespiratory functions. This study aimed at determining the function of the Pa5 on the cardiovascular component of the somatosensory reflex (SSR) to sciatic nerve stimulation (SNS) in paralyzed and artificially-ventilated rats following Pa5 chemical lesions (ibotenic acid), synaptic transmission blockade (CoCl(2)), local anaesthetics (lidocaine) or desensitization of primary afferent fibers (capsaicin). the pressor response to sciatic nerve stimulation at 0.6 mA and 20 Hz (14 +/- 1 mm Hg) was strongly attenuated by contra-(-80%) or bilateral (-50%) paratrigeminal nucleus lesions. Ipsilateral Pa5 lesions only attenuated the response to 0.1 mA, 20 Hz SNS (-55%). Cobalt chloride or lidocaine injected in the contralateral paratrigeminal nucleus also attenuated the SSR. in capsaicin-treated animals, the pressor responses to 0.1 mA were abolished, whereas the responses to SNS at 0.6 mA were increased from 65 to 100% depending on the stimulus frequency. the paratrigeminal nucleus receives both, excitatory and inhibitory components; the later apparently involving capsaicin-sensitive fiber inputs mostly to the ipsilateral site whereas the capsaicin insensitive excitatory components that respond to high or low frequency stimulation, respectively, target the contralateral and ipsilateral sites. Thus, the paratrigeminal nucleus mediates excitatory and inhibitory components of the somatosensory reflex, representing a primary synapse site in the brain for nociceptive inputs from the sciatic innervation field. (C) 2008 Published by Elsevier B.V.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationInst Israelita Ensino & Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliationUniv Montreal, Dept Phys, Montreal, PQ H3C 3J7, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent72-79
dc.identifierhttps://dx.doi.org/10.1016/j.autneu.2008.04.003
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 140, n. 1-2, p. 72-79, 2008.
dc.identifier.doi10.1016/j.autneu.2008.04.003
dc.identifier.issn1566-0702
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/30696
dc.identifier.wosWOS:000257527700010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectNociceptionen
dc.subjectCardiovascular reflexen
dc.subjectSciatic nerveen
dc.subjectPrimary afferent fibersen
dc.subjectSynaptic transmissionen
dc.subjectParatrigeminal nucleus lesionen
dc.titleThe role of the paratrigeminal nucleus in the pressor response to sciatic nerve stimulation in the raten
dc.typeinfo:eu-repo/semantics/article
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