The use of vancomycin with its therapeutic and adverse effects: a review

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dc.contributor.authorBruniera, F. R.
dc.contributor.authorFerreira, F. M.
dc.contributor.authorSaviolli, L. R. M. [UNIFESP]
dc.contributor.authorBacci, M. R.
dc.contributor.authorFeder, D.
dc.contributor.authorLuz Goncalves Pedreira, M. da [UNIFESP]
dc.contributor.authorPeterlini, M. A. Sorgini [UNIFESP]
dc.contributor.authorAzzalis, L. A. [UNIFESP]
dc.contributor.authorJunqueira, V. B. Campos [UNIFESP]
dc.contributor.authorFonseca, F. L. A. [UNIFESP]
dc.contributor.institutionFac Med ABC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:22:30Z
dc.date.available2018-06-15T17:22:30Z
dc.date.issued2015-01-01
dc.description.abstractOBJECTIVE: Vancomycin (VCM) is a tricyclic glycopeptide antibiotic produced by Streptococcus orientalis. Widely used in hospitals, it is indicated to fight severe infections caused by Gram-positive bacteria, especially with the advent of MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci among others. Furthermore, it is indicated for the treatment of patients allergic to penicillins and cephalosporins. Dose recommendations, dilution rates and types of infusion are controversial and also result in toxic effects. Aim of this paper was to perform a literature review showing the therapeutic and adverse effects of vancomycin.MATERIALS AND METHODS: This is a literature review of recent articles published on MEDLINE and SciELO databases in English, Portuguese and Spanish.RESULTS: The main adverse effects of vancomycin are: hypotension, phlebitis, nephrotoxicity, ototoxicity, hypersensitivity reactions, red man syndrome, neutropenia, chills, fever, interstitial nephritis.CONCLUSIONS: The use of vancomycin is still very common; however, inadequate doses and prolonged therapy pose a risk of increasing minimum inhibitory concentrations (MICs), resulting in subtherapeutic levels, treatment failures and toxicity. Therefore, further studies should be conducted to optimize the administration of vancomycin, monitoring treatments from the beginning in order to ensure a safe and effective use of the drug.en
dc.description.affiliationFac Med ABC, Dept Morphol, Discipline Pharmacol, Santo Andre, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Earth Exact Sci Dept, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biol Sci, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Earth Exact Sci Dept, Inst Environm Chem & Pharmaceut Sci, Diadema, Brazil
dc.description.sourceWeb of Science
dc.format.extent694-700
dc.identifierhttp://www.europeanreview.org/article/8585
dc.identifier.citationEuropean Review For Medical And Pharmacological Sciences. Rome: Verduci Publisher, v. 19, n. 4, p. 694-700, 2015.
dc.identifier.issn1128-3602
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43631
dc.identifier.wosWOS:000351491900027
dc.language.isoeng
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVancomycinen
dc.subjectToxicityen
dc.subjectEndothelial injuryen
dc.subjectOxidative stressen
dc.titleThe use of vancomycin with its therapeutic and adverse effects: a reviewen
dc.typeinfo:eu-repo/semantics/article
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