The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice

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dc.contributor.authorPaula-Freire, Lyvia Izaura Gomes de [UNIFESP]
dc.contributor.authorAndersen, M. L. [UNIFESP]
dc.contributor.authorGama, V. S.
dc.contributor.authorMolska, G. R. [UNIFESP]
dc.contributor.authorCarlini, E. L. A. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Sao Judas Tadeu
dc.date.accessioned2016-01-24T14:35:19Z
dc.date.available2016-01-24T14:35:19Z
dc.date.issued2014-02-15
dc.description.abstractTrans-caryophyllene is a sesquiterpene present in many medicinal plants' essential oils, such as Ocimum gratissimum and Cannabis sativa. in this study, we evaluated the antinociceptive activity of transcaryophyllene in murine models of acute and chronic pain and the involvement of trans-caryophyllene in the opioid and endocannabinoid systems. Acute pain was determined using the hot plate test (thermal nociception) and the formalin test (inflammatory pain). the chronic constriction injury (CCI) of the sciatic nerve induced hypernociception was measured by the hot plate and von Frey tests. To elucidate the mechanism of action, mice were pre-treated with naloxone or AM630 30 min before the trans-caryophyllene treatment. Afterwards, thermal nociception was evaluated. the levels of IL-1 beta were measured in CCI-mice by ELISA. Trans-caryophyllene administration significantly minimized the pain in both the acute and chronic pain models. the antinociceptive effect observed during the hot plate test was reversed by naloxone and AM630, indicating the participation of both the opioid and endocannabinoid system. Trans-caryophyllene treatment also decreased the IL-1 beta levels. These results demonstrate that transcaryophyllene reduced both acute and chronic pain in mice, which may be mediated through the opioid and endocannabinoid systems. (C) 2013 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Fac Farm, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med Prevent, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med Prevent, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCentro Brasileiro de Informacoes sobre Drogas Psicotropicas (CEBRID)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 09/51881-1
dc.format.extent356-362
dc.identifierhttp://dx.doi.org/10.1016/j.phymed.2013.08.006
dc.identifier.citationPhytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 21, n. 3, p. 356-362, 2014.
dc.identifier.doi10.1016/j.phymed.2013.08.006
dc.identifier.issn0944-7113
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37441
dc.identifier.wosWOS:000334012400023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhytomedicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMedicinal plantsen
dc.subjectTrans-caryophylleneen
dc.subjectOpioid systemen
dc.subjectEndocannabinoid systemen
dc.subjectInterleukin 1 betaen
dc.subjectPainen
dc.titleThe oral administration of trans-caryophyllene attenuates acute and chronic pain in miceen
dc.typeinfo:eu-repo/semantics/article
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