Hemodynamic effects elicited by microinjection of glutamatergic agonists into NTS of conscious rats

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dc.contributor.authorDias, Ana Carolina Rodrigues [UNIFESP]
dc.contributor.authorTalman, William T.
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Iowa
dc.contributor.institutionVet Affairs Med Ctr
dc.date.accessioned2018-06-15T13:20:13Z
dc.date.available2018-06-15T13:20:13Z
dc.date.issued2001-09-01
dc.description.abstractIn this study, we characterized the arterial pressure, heart rate, and regional vascular conductance responses elicited by unilateral microinjection of ionotropic glutamatergic agonists N-methyl-D-aspartic acid (NMDA and non-NMDA) into the nucleus of tractus solitarius (NTS) of conscious rats. Microinjections of NMDA and S-alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) caused changes in mean arterial pressure (MAP). Lower doses elicited decreases in MAP, whereas higher doses elicited biphasic responses (decreases followed by increases). Both agonists induced bradycardia and elicited dose-dependent vasoconstriction in the renal, mesenteric, and hindquarter beds. AMPA elicited delayed vasodilation in the hindquarter bed but NMDA did not. Bradycardia and initial hypotension produced by each agonist were abolished by systemic administration of the muscarinic antagonist methylatropine. However, methylatropine did not affect either the vasoconstriction or the vasodilatation. The contrasting hemodynamic effects produced by NMDA and AMPA could be caused by activation of differential subsets of NTS neurons. Preferential activation of one subset could produce the NMDA-related responses, whereas activation of another subset would elicit AMPA-related responses.en
dc.description.affiliationUNIFESP, Escola Paulista Med, Dept Physiol, BR-04023060 Sao Paulo, Brazil
dc.description.affiliationUniv Iowa, Dept Neurol, Iowa City, IA 52242 USA
dc.description.affiliationVet Affairs Med Ctr, Iowa City, IA 52242 USA
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, Dept Physiol, BR-04023060 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentH1026-H1034
dc.identifierhttp://ajpheart.physiology.org/content/281/3/H1026
dc.identifier.citationAmerican Journal Of Physiology-heart And Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 281, n. 3, p. H1026-H1034, 2001.
dc.identifier.issn0363-6135
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42350
dc.identifier.wosWOS:000170705100007
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal Of Physiology-heart And Circulatory Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectarterial pressureen
dc.subjectregional vascular conductanceen
dc.subjectnucleus tractus solitariien
dc.titleHemodynamic effects elicited by microinjection of glutamatergic agonists into NTS of conscious ratsen
dc.typeinfo:eu-repo/semantics/article
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