Histoplasmosis in HIV-positive patients in Ceara, Brazil: clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates

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dc.contributor.authorBrilhante, Raimunda S. N.
dc.contributor.authorFechine, Maria A. B.
dc.contributor.authorMesquita, Jaco R. L.
dc.contributor.authorCordeiro, Rossana A.
dc.contributor.authorRocha, Marcos F. G.
dc.contributor.authorMonteiro, Andre J.
dc.contributor.authorLima, Rita A. C.
dc.contributor.authorCaetano, Erica P.
dc.contributor.authorPereira, Juliana F.
dc.contributor.authorCastelo-Branco, Debora S. C. M.
dc.contributor.authorCamargo, Zoilo P. [UNIFESP]
dc.contributor.authorSidrim, Jose J. C.
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniv Estadual Ceara
dc.contributor.institutionHosp Sao Jose
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:32Z
dc.date.available2016-01-24T14:27:32Z
dc.date.issued2012-08-01
dc.description.abstractThis study contains a descriptive analysis of histoplasmosis in AIDS patients between 2006 and 2010 in the state of Ceara, Brazil. Additionally, the in vitro susceptibility of Histoplasma capsulatum isolates obtained during this period was assessed. We report 208 cases of patients with histoplasmosis and AIDS, describing the epidemiological, clinical, laboratory and therapeutic aspects. the in vitro antifungal susceptibility test was carried out by the microdilution method, according to Clinical and Laboratory Standards Institute, with H. capsulatum in the filamentous and yeast phases, against the antifungals amphotericin B, fluconazole, itraconazole, voriconazole and caspofungin. in 38.9% of the cases, histoplasmosis was the first indicator of AIDS and in 85.8% of the patients the CD4 cell count was lower than 100 cells/mm(3). the lactate dehydrogenase levels were high in all the patients evaluated, with impairment of hepatic and renal function and evolution to death in 42.3% of the cases. the in vitro susceptibility profile demonstrated there was no antifungal resistance among the isolates evaluated. There was a significant increase in the number of histoplasmosis cases in HIV-positive patients during the period surveyed in the state of Ceara, northeastern Brazil, but no antifungal resistance among the recovered isolates of H. capsulatum. (C) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Ceara, Specialized Med Mycol Ctr, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Microbiol, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Postgrad Program Med Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Ceara, Postgrad Program Vet Sci, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara, Brazil
dc.description.affiliationHosp Sao Jose, Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCNPq: 562296/2010-7
dc.description.sponsorshipIDCNPq: 552161/2011-0
dc.description.sponsorshipIDCNPq: 304779/2011-3
dc.description.sponsorshipIDCAPES: 2103/2009
dc.format.extent484-488
dc.identifierhttp://dx.doi.org/10.1016/j.trstmh.2012.05.003
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. New York: Elsevier B.V., v. 106, n. 8, p. 484-488, 2012.
dc.identifier.doi10.1016/j.trstmh.2012.05.003
dc.identifier.issn0035-9203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35143
dc.identifier.wosWOS:000307032700006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBrazilen
dc.subjectAIDSen
dc.subjectHistoplasmosisen
dc.subjectAntifungal susceptibilityen
dc.subjectHistoplasma capsulatumen
dc.subjectEpidemiologyen
dc.titleHistoplasmosis in HIV-positive patients in Ceara, Brazil: clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolatesen
dc.typeinfo:eu-repo/semantics/article
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