Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

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dc.contributor.authorBeirão, Elisa Maria
dc.contributor.authorFurtado, Juvencio Jose Duailibe
dc.contributor.authorGirardello, Raquel [UNIFESP]
dc.contributor.authorFerreira Filho, Heli
dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.institutionHospital Heliópolis
dc.contributor.institutionHospital Heliópolis Department of Infectious Diseases
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHospital Heliópolis Microbiology Laboratory
dc.date.accessioned2015-06-14T13:42:53Z
dc.date.available2015-06-14T13:42:53Z
dc.date.issued2011-02-01
dc.description.abstractIn 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.en
dc.description.affiliationHospital Heliópolis
dc.description.affiliationHospital Heliópolis Department of Infectious Diseases
dc.description.affiliationUNIFESP-EPM
dc.description.affiliationHospital Heliópolis Microbiology Laboratory
dc.description.affiliationUNIFESP-EPM Infectious Diseases Division
dc.description.affiliationUnifespUNIFESP, EPM, Infectious Diseases Division
dc.description.sourceSciELO
dc.format.extent69-73
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702011000100013
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 1, p. 69-73, 2011.
dc.identifier.doi10.1590/S1413-86702011000100013
dc.identifier.fileS1413-86702011000100013.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702011000100013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6270
dc.identifier.wosWOS:000288385100013
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKlebsiella pneumoniaen
dc.subjectKPCen
dc.subjecthospital infectionen
dc.subjectcarbapenemaseen
dc.titleClinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazilen
dc.typeinfo:eu-repo/semantics/article
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