Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter

Página do item simplificado
dc.contributor.authorFelizardo, Raphael José Ferreira [UNIFESP]
dc.contributor.authorCâmara, Niels Olsen Saraiva [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:31:53Z
dc.date.available2016-01-24T14:31:53Z
dc.date.issued2013-06-28
dc.description.abstractOchratoxin A (OTA) is a secondary metabolite of Aspergillus and Penicillium, microorganisms that can be hazardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular carcinoma (HCC) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. in a recent study, Ibrahim et al proposed a correlation between the incidence of HCC and contamination with OTA. Analysis of OTA in serum samples showed that HCC patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in HCC patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of HCC should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods. (C) 2013 Baishideng. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Nephrol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Nephrol, BR-05508900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent3723-3725
dc.identifierhttp://dx.doi.org/10.3748/wjg.v19.i24.3723
dc.identifier.citationWorld Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 19, n. 24, p. 3723-3725, 2013.
dc.identifier.doi10.3748/wjg.v19.i24.3723
dc.identifier.issn1007-9327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36435
dc.identifier.wosWOS:000321115100002
dc.language.isoeng
dc.publisherBaishideng Publ Grp Co Ltd
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOchratoxin Aen
dc.subjectMycotoxinen
dc.subjectFood contaminationen
dc.subjectHepatocellular carcinomaen
dc.subjectLiver canceren
dc.subjectEgypten
dc.titleHepatocellular carcinoma and food contamination: Ochratoxin A as a great prompteren
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos