Mutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugs

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dc.contributor.authorAraldi, Rodrigo Pinheiro
dc.contributor.authorRechiutti, Bruna Mendes
dc.contributor.authorMendes, Thais Biude [UNIFESP]
dc.contributor.authorIto, Eliana Tiemi
dc.contributor.authorSouza, Edislaine Barreto
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:00Z
dc.date.available2016-01-24T14:35:00Z
dc.date.issued2014-01-01
dc.description.abstractObesity is one of the most important nutritional disorders, and can be currently considered as an epidemic. Although there are few weight reduction drugs available on the market, some new drug candidates have been proposed, including Cordia ecalyculata, a Brazilian plant with anorectic properties, and Spirulina maxima, a cyanobacterium with antioxidant and anti-genotoxic activity. in this study, we evaluated the mutagenic potential of C. ecalyculata at doses of 150, 300, and 500 mg/kg alone and in association with S. maxima at doses of 75, 150, and 250 mg/kg, respectively, through an in vivo micronucleus test, using mice of both sexes, and an in vitro micronucleus test and comet assay, using human peripheral blood. for all tests, cyclophosphamide was used as a positive control. the results showed that treatment of 300 mg/kg C. ecalyculata and the combination treatment of 500 mg/kg C. ecalyculata with 250 mg/kg S. maxima resulted in anorectic effects. the mutagenic tests did not reveal any clastogenic or genotoxic activity for any treatment, indicating that these candidates could be marketed as weight-reduction drugs. Moreover, the drugs contain chemo-preventive substances that can protect against tumorigenesis, which has been associated with obesity.en
dc.description.affiliationUniv Estadual Paulista, Lab Biol Mol Genet & Mutagenese, Assis, SP, Brazil
dc.description.affiliationUniv São Paulo, Programa Posgrad Interunidades Biotecnol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Programa Posgrad Biol Estrutural & Func, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Programa Posgrad Biol Estrutural & Func, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2010/05649-7
dc.format.extent5207-5220
dc.identifierhttp://dx.doi.org/10.4238/2014.July.7.14
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 13, n. 3, p. 5207-5220, 2014.
dc.identifier.doi10.4238/2014.July.7.14
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37192
dc.identifier.wosWOS:000340383600053
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCordia ecalyculataen
dc.subjectSpirulina maximaen
dc.subjectMicronucleusen
dc.subjectComet assayen
dc.subjectMutagenesisen
dc.titleMutagenic potential of Cordia ecalyculata alone and in association with Spirulina maxima for their evaluation as candidate anti-obesity drugsen
dc.typeinfo:eu-repo/semantics/article
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