Cardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized rats

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dc.contributor.authorSilva, N.f.
dc.contributor.authorPires, J.g.p.
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorFuturo Neto, H.a.
dc.contributor.institutionUniversidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências Fisiológicas
dc.contributor.institutionFAESA Faculdade de Saúde de Vitória
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:29:33Z
dc.date.available2015-06-14T13:29:33Z
dc.date.issued2001-12-01
dc.description.abstractThe role of the caudal pressor area (CPA) in the maintenance of vasomotor tonus in anesthetized and decerebrate animals has been clearly established. In conscious animals, however, the participation of CPA in the cardiovascular control remains to be fully elucidated. In the present study, unilateral L-glutamate (L-Glu) (10 and/or 20 nmol/70 nl) microinjection into CPA, in conscious male Wistar rats (250-280 g) caused a significant increase in mean arterial blood pressure (MAP; control: 112 ± 1.9 mmHg; after 20 nmol L-Glu: 139 ± 4.5 mmHg, N = 12, P<0.05) and respiratory rate (control: 81 ± 3.5 breaths/min; after 10 nmol L-Glu: 92 ± 3 breaths/min, P<0.05; after 20 nmol L-Glu: 104 ± 5 breaths/min, N = 6, P<0.05). The subsequent anesthesia with urethane caused a significant increase in basal respiratory frequency (conscious: 81 ± 3.5 breaths/min; under urethane: 107 ± 1.3 breaths/min, N = 6, P<0.05). Anesthesia also significantly attenuated L-Glu-evoked pressor (conscious: deltaMAP = +27 mmHg; anesthetized: deltaMAP = +18 mmHg, P<0.05) and respiratory responses. These results suggest that glutamatergic receptors in the CPA are involved in cardiovascular and respiratory modulation in conscious rats.en
dc.description.affiliationUniversidade Federal do Espírito Santo Centro Biomédico Departamento de Ciências Fisiológicas
dc.description.affiliationFAESA Faculdade de Saúde de Vitória
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Disciplina de Fisiologia Cardiovascular
dc.description.affiliationUnifespUNIFESP, Disciplina de Fisiologia Cardiovascular
dc.description.sourceSciELO
dc.format.extent1603-1606
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001001200013
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 12, p. 1603-1606, 2001.
dc.identifier.doi10.1590/S0100-879X2001001200013
dc.identifier.fileS0100-879X2001001200013.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2001001200013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1300
dc.identifier.wosWOS:000172765500013
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcaudal pressor areaen
dc.subjectventrolateral medullaen
dc.subjectblood pressureen
dc.subjectL-glutamateen
dc.subjectrespirationen
dc.titleCardiovascular and respiratory responses to microinjection of L-glutamate into the caudal pressor area in conscious and anesthetized ratsen
dc.typeinfo:eu-repo/semantics/article
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