Redução no nível de ansiedade, aumento da atividade locomotora e déficit na memória de trabalho de ratos com epilepsia do lobo temporal
Arquivos
Data
2014
Autores
Ramos, Fabiane Ochai 
Orientadores
Scorza, Fulvio Alexandre
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A epilepsia e caracterizada por crises espontaneas recorrentes, desencadeadas pela hiperexcitabilidade neuronal, acometendo aproximadamente 50 milhoes de pessoas no mundo. Dentre as epilepsias, a epilepsia do lobo temporal (ELT) e a mais comum e afeta cerca de 40% dos pacientes. O Transtorno do Deficit de Atencao e Hiperatividade (TDAH) representa uma das comorbidades mais comum da epilepsia com prevalencia maior do que 30%. A DSM-IV subdivide o TDAH em tres tipos, no primeiro tipo se observa o predominio de sintomas de desatencao; o segundo ha predominancia de hiperatividade/impulsividade e; o terceiro se caracteriza pela combinacao dos dois primeiros tipos. Embora exista uma relacao bem definida entre epilepsia e TDAH, os mecanismos dessa comorbidade ainda nao foram completamente esclarecidos. O objetivo do presente estudo foi analisar alteracoes comportamentais TDAH-like em ratos Wistar machos com ELT induzida pelo metodo da pilocarpina. Foram utilizados os testes de campo aberto, labirinto em cruz elevado e caixa de condicionamento operante para avaliacao dos comportamentos. Os resultados apresentados mostram evidencias que animais adultos com ELT pelo modelo da pilocarpina apresentaram aumento da atividade locomotora e reducao do nivel de ansiedade, prejuizo na memoria de trabalho viso-espacial, sem evidencias de impulsividade. Os resultados nao permitem descartar a possibilidade de deficit de atencao e apontam para a presenca de hiperatividade, sintomas caracteristicos de TDAH, porem mais estudos serao necessarios para avaliar a atencao e a impulsividade
Epilepsy is characterized by recurrent spontaneous seizures triggered by neuronal hyperexcitability, affecting approximately 50 million people worldwide. Among the epilepsy, temporal lobe epilepsy (TLE) is the most common and affects about 40% of patients. Disorder Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common comorbidities of epilepsy with greater than 30% prevalence. The DSM - IV subdivided the ADHD into three types, the first type is observed the predominance of symptoms of inattention; the second, predominance of hyperactivity / impulsivity and; the third is characterized by the combination of the first two types. Although there is a well defined relationship between epilepsy and ADHD, the mechanisms of this comorbidity were poorly understood. The aim of this study was to assess ADHD-like behavioral changes in male Wistar rats with TLE induced by pilocarpine method. Tests of open field, elevated plus maze and operant conditioning box were used to assess the behaviors. The results show evidence that adult animals with TLE by pilocarpine model presented increased locomotor activity and reduced level of anxiety like behavior, impairment in visuospatial working memory, with no evidence of impulsivity. The results don’t dismiss the possibility of attention deficit and point to the presence of hyperactivity, characteristic symptoms of ADHD, but more studies are necessary to evaluate the attention and impulsivity.
Epilepsy is characterized by recurrent spontaneous seizures triggered by neuronal hyperexcitability, affecting approximately 50 million people worldwide. Among the epilepsy, temporal lobe epilepsy (TLE) is the most common and affects about 40% of patients. Disorder Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common comorbidities of epilepsy with greater than 30% prevalence. The DSM - IV subdivided the ADHD into three types, the first type is observed the predominance of symptoms of inattention; the second, predominance of hyperactivity / impulsivity and; the third is characterized by the combination of the first two types. Although there is a well defined relationship between epilepsy and ADHD, the mechanisms of this comorbidity were poorly understood. The aim of this study was to assess ADHD-like behavioral changes in male Wistar rats with TLE induced by pilocarpine method. Tests of open field, elevated plus maze and operant conditioning box were used to assess the behaviors. The results show evidence that adult animals with TLE by pilocarpine model presented increased locomotor activity and reduced level of anxiety like behavior, impairment in visuospatial working memory, with no evidence of impulsivity. The results don’t dismiss the possibility of attention deficit and point to the presence of hyperactivity, characteristic symptoms of ADHD, but more studies are necessary to evaluate the attention and impulsivity.
Descrição
Citação
RAMOS, Fabiane Ochai. Redução no nível de ansiedade, aumento da atividade locomotora e déficit na memória de trabalho de ratos com epilepsia do lobo temporal. 2014. 63f. Dissertação (Mestrado) - Escola Paulista de Medicina, Universidade Federal de São Paulo. São Paulo, 2014.