Old antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomes

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dc.citation.issue5
dc.citation.volume49
dc.contributor.authorKaye, Keith S.
dc.contributor.authorGales, Ana C. [UNIFESP]
dc.contributor.authorDubourg, Gregory
dc.coverageAmsterdam
dc.date.accessioned2020-07-13T11:53:22Z
dc.date.available2020-07-13T11:53:22Z
dc.date.issued2017
dc.description.abstractAntimicrobial resistance is a major and emerging threat worldwide. New antimicrobials have been unable to meet the resistance challenge, and treatment options are limited for a growing number of resistant pathogens. More and more clinicians are relying on older antimicrobials for the treatment of multidrug-resistant (MDR) bacteria. Some older antimicrobials have maintained excellent in vitro activity against highly resistant pathogens. In some instances, use of older agents is limited by unfavourable pharmacokinetic/pharmacodynamic characteristics and/or toxicities. In general, clinical data pertaining to the use of older agents for the treatment of MDR pathogens are scarce. Research efforts should be focused on the evaluation of older agents for the treatment of MDR pathogens as well as evaluating how these agents perform in complex patient populations with various and multiple co-morbid conditions. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.en
dc.description.affiliationUniv Michigan Hlth Syst, Div Infect Dis, Dept Med, Ann Arbor, MI USA
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Infect Dis, Sao Paulo, Brazil
dc.description.affiliationUniv Marseille, Inst Hosp Univ IHU Mediterranee Infect, AP HM, Federat Bacteriol Hyg Virol,Hosp Ctr Timone,Pole, Marseille, France
dc.description.affiliationUniv Aix Marseille, URMITE, UM 63, CNRS 7278,IRD 198,INSERM,U1095,Fac Med, Marseille, France
dc.description.affiliationUniv Aix Marseille, URMITE, UM 63, CNRS 7278,IRD 198,INSERM,U1095,Fac Pharm, Marseille, France
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Internal Med, Div Infect Dis, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (DMID)
dc.description.sponsorshipIDNational Institute of Allergy and Infectious Diseases DMID: 10-0065
dc.description.sponsorshipIDNational Institute of Allergy and Infectious Diseases DMID: R01-AI119446-01
dc.format.extent542-548
dc.identifierhttp://dx.doi.org/10.1016/j.ijantimicag.2016.11.020
dc.identifier.citationInternational Journal Of Antimicrobial Agents. Amsterdam, v. 49, n. 5, p. 542-548, 2017.
dc.identifier.doi10.1016/j.ijantimicag.2016.11.020
dc.identifier.issn0924-8579
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54574
dc.identifier.wosWOS:000402467500004
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofInternational Journal Of Antimicrobial Agents
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPolymyxinsen
dc.subjectSulphonamidesen
dc.subjectAminoglycosidesen
dc.subjectTetracyclinesen
dc.subjectFosfomycinen
dc.subjectMultidrug-resistanten
dc.titleOld antibiotics for multidrug-resistant pathogens: from in vitro activity to clinical outcomesen
dc.typeinfo:eu-repo/semantics/article
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