Efficacy of antidepressants on measures of workplace functioning in major depressive disorder: A systematic review

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dc.citation.volume227
dc.contributor.authorLee, Yena
dc.contributor.authorRosenblat, Joshua D.
dc.contributor.authorLee, JungGoo
dc.contributor.authorCarmona, Nicole E.
dc.contributor.authorSubramaniapillai, Mehala
dc.contributor.authorShekotikhina, Margarita
dc.contributor.authorMansur, Rodrigo B.
dc.contributor.authorBrietzke, Elisa [UNIFESP}
dc.contributor.authorLee, Jae-Hon
dc.contributor.authorHo, Roger C.
dc.contributor.authorYim, Samantha J.
dc.contributor.authorMcIntyre, Roger S.
dc.coverageAmsterdam
dc.date.accessioned2020-07-08T13:09:47Z
dc.date.available2020-07-08T13:09:47Z
dc.date.issued2018
dc.description.abstractIntroduction: Work-related disability and productivity loss in Major Depressive Disorder (MDD) are critical determinants of patient quality of life and contribute significantly to the human and economic costs of MDD. Notwithstanding the return to work and pre-morbid levels of functioning as a critical therapeutic objective among individuals with MDD, it is unclear whether antidepressant treatment significantly and reliably improves measures of workplace functioning. Herein, we investigate to what extent antidepressant treatment improves workplace functioning among adults with MDD. Methods: We conducted a systematic review of randomized, double-blind, placebo-controlled or active comparator clinical trials primarily or secondarily investigating the efficacy of antidepressant agents on subjective ratings of workplace functioning and/or measures of work absence. Results: Thirteen placebo-controlled and four active comparator clinical trials reported on the efficacy of agomelatine, bupropion, desvenlafaxine, duloxetine, fluoxetine, levomilnacipran, paroxetine, sertraline, venlafaxine, or vortioxetine on subjective measures of workplace impairment. Overall, antidepressant treatment improved standardized measures of workplace functioning (e.g., Sheehan Disability Scale-work item). One placebo-controlled trial of agomelatine and one clinical trial comparing the efficacy of vortioxetine to that of venlafaxine had mixed results on measures of work absence. Limitations: Included interventional trials evaluated work-related disability as a secondary outcome using subjective rating scales. Conclusion: Extant data suggest that antidepressant treatment improves workplace outcomes in MDD. The capability of antidepressants in improving measures of workplace functioning should be considered in cost-benefit analyses to better inform cost-modelling studies pertaining to antidepressant therapy.en
dc.description.affiliationUniv Toronto, Inst Med Sci, Toronto, ON, Canada
dc.description.affiliationUniv Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Psychiat, Toronto, ON, Canada
dc.description.affiliationInje Univ, Paik Inst Clin Res, Busan, South Korea
dc.description.affiliationInje Univ, Grad Sch, Dept Hlth Sci & Technol, Busan, South Korea
dc.description.affiliationHaeundae Paik Hosp, Sch Med, Dept Psychiat, Busan, South Korea
dc.description.affiliationUniv Ottawa, Dept Psychiat, Ottawa, ON, Canada
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationKorea Univ, Ansan Hosp, Dept Psychiat, Coll Med, Ansan, South Korea
dc.description.affiliationNatl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore
dc.description.affiliationUniv Toronto, Dept Pharmacol, Toronto, ON, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent406-415
dc.identifierhttp://dx.doi.org/10.1016/j.jad.2017.11.003
dc.identifier.citationJournal Of Affective Disorders. Amsterdam, v. 227, p. 406-415, 2018.
dc.identifier.doi10.1016/j.jad.2017.11.003
dc.identifier.issn0165-0327
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54202
dc.identifier.wosWOS:000424323600055
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Affective Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDepressionen
dc.subjectWorken
dc.subjectFunctioningen
dc.subjectAntidepressanten
dc.subjectQuality of lifeen
dc.subjectFunctional outcomesen
dc.subjectDisabilityen
dc.subjectCost modellingen
dc.titleEfficacy of antidepressants on measures of workplace functioning in major depressive disorder: A systematic reviewen
dc.typeinfo:eu-repo/semantics/article
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