Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

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dc.contributor.authorObstein, Keith L.
dc.contributor.authorMartins, Fernanda P. [UNIFESP]
dc.contributor.authorFernandez-Esparrach, Gloria
dc.contributor.authorThompson, Christopher C.
dc.contributor.institutionBrigham & Womens Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Clin Barcelona
dc.date.accessioned2016-01-24T13:59:19Z
dc.date.available2016-01-24T13:59:19Z
dc.date.issued2010-02-14
dc.description.abstractAIM: To assess the feasibility of endoscopic ultrasound (EUS)-guided celiac plexus neurolysis (CPN) using a poloxamer.METHODS: in this prospective evaluation, six Yorkshire pigs underwent EUS-guided CPN. Three received an injection of 10 mL of 0.25% Lidocaine plus methylene blue (group 1) and three received an injection of 10 mL of 0.25% Lidocaine plus blue colored poloxamer (PS137-25) (group 2). Necropsy was performed immediately after the animals were sacrificed. the abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS: EUS-guided CPN was successfully performed in all 6 pigs without immediate complication. Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1. the blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta, in the exact location of the celiac plexus in group 2.CONCLUSION: EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible. the presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. (C) 2010 Baishideng. All rights reserved.en
dc.description.affiliationBrigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA
dc.description.affiliationUniversidade Federal de São Paulo, BR-04023062 São Paulo, Brazil
dc.description.affiliationHosp Clin Barcelona, Dept Gastroenterol, Endoscopy Unit, E-08036 Barcelona, Spain
dc.description.affiliationUnifespUniversidade Federal de São Paulo, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGeneralitat de Catalunya (AGAUR)
dc.description.sponsorshipIDGeneralitat de Catalunya (AGAUR): BE-100022
dc.format.extent728-731
dc.identifierhttp://dx.doi.org/10.3748/wjg.v16.i6.728
dc.identifier.citationWorld Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 6, p. 728-731, 2010.
dc.identifier.doi10.3748/wjg.v16.i6.728
dc.identifier.issn1007-9327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32269
dc.identifier.wosWOS:000274459200010
dc.language.isoeng
dc.publisherW J G Press
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCeliac plexus neurolysisen
dc.subjectCeliac plexus blockadeen
dc.subjectEndoscopic ultrasounden
dc.subjectPolymeren
dc.titleEndoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymeren
dc.typeinfo:eu-repo/semantics/article
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