Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

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dc.contributor.authorNeves, Rafael Scarpa da Costa [UNIFESP]
dc.contributor.authorTudesco, Ivanda de Souza Silva [UNIFESP]
dc.contributor.authorJardim, Anaclara Prada [UNIFESP]
dc.contributor.authorCaboclo, Luís Otávio Sales Ferreira [UNIFESP]
dc.contributor.authorLancellotti, Carmen Lucia Penteado
dc.contributor.authorFerrari-Marinho, Taissa
dc.contributor.authorHamad, Ana Paula Andrade [UNIFESP]
dc.contributor.authorMarinho, Murilo Martinez [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorScorza, Carla Alessandra [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa São Paulo
dc.contributor.institutionAFIP
dc.date.accessioned2016-01-24T14:27:54Z
dc.date.available2016-01-24T14:27:54Z
dc.date.issued2012-11-01
dc.description.abstractPurpose: We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MILE) and mesial temporal sclerosis (MTS).Method: Hippocampal specimens from 54 patients with MTLE (27 patients with right MILE and 27 with left MTLE) and unilateral MTS, who were separated into CCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.Results: CCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. the presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.Conclusion: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined. (c) 2012 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Escola Paulista Med, Unidade Pesquisa & Tratamento Epilepsias, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationSanta Casa São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationAFIP, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosci, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Escola Paulista Med, Unidade Pesquisa & Tratamento Epilepsias, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosci, Escola Paulista Med, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipInstituto Nacional de Neurociencia Translacional (INNT), Brazil
dc.format.extent685-690
dc.identifierhttp://dx.doi.org/10.1016/j.seizure.2012.07.008
dc.identifier.citationSeizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 21, n. 9, p. 685-690, 2012.
dc.identifier.doi10.1016/j.seizure.2012.07.008
dc.identifier.fileWOS000309442300004.pdf
dc.identifier.issn1059-1311
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35423
dc.identifier.wosWOS:000309442300004
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofSeizure-european Journal of Epilepsy
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMesial temporal lobe epilepsyen
dc.subjectMenial temporal sclerosisen
dc.subjectDentate gyrosen
dc.subjectGranule cell dispersionen
dc.subjectMemoryen
dc.titleGranule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsyen
dc.typeinfo:eu-repo/semantics/article
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