The role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: Evidence from calretinin and neo-timm staining in pilocarpine-epileptic mice

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dc.contributor.authorSilva, Julieta Gonçalves [UNIFESP]
dc.contributor.authorMello, Luiz Eugenio Araujo de Moraes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:58Z
dc.date.available2016-01-24T12:30:58Z
dc.date.issued2000-01-01
dc.description.abstractMossy fiber sprouting is a major anatomical reorganization seen in patients with temporal lobe epilepsy and animal models of epilepsy. the final outcome of this reorganization is viewed by many as epileptogenic. Yet, important and relevant data from both human and animal models of epilepsy challenge this prevailing view. Regardless of the outcome of this debate, understanding of the mechanisms that underlie massy fiber sprouting (MFS) might contribute to our understanding of both the adaptive and maladaptive changes that take place in the nervous system after injury. Available evidence suggests that two events might be crucial for mossy fibers to sprout in epilepsy: the death of mossy cells and the synthesis of trophic factors. the availability of means that prevent MFS, which is normally triggered after induction of status epilepticus, allow for the testing of hypotheses regarding the need for and the sufficiency of specific events for mossy fibers to sprout. We present data on a specific marker for mossy cells, calretinin, in the pilocarpine model of epilepsy in mice. Our data suggest that in the presence of a protein synthesis inhibitor status epilepticus-induced death of mossy cells is not sufficient to trigger mossy fiber sprouting. We suggest that both events, mossy cell death and synthesis of trophic factors, might be necessary for robust MFS to ensue.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extentS18-S23
dc.identifierhttp://dx.doi.org/10.1111/j.1528-1157.2000.tb01551.x
dc.identifier.citationEpilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 41, p. S18-S23, 2000.
dc.identifier.doi10.1111/j.1528-1157.2000.tb01551.x
dc.identifier.issn0013-9580
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26205
dc.identifier.wosWOS:000089156500005
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofEpilepsia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectstatus epilepticusen
dc.subjectmossy fiber sproutingen
dc.subjectmossy cellsen
dc.subjectdentate gyrusen
dc.subjectgranule cellsen
dc.subjectGAP-43en
dc.subjecthippocampusen
dc.subjecttemporal lobe epilepsyen
dc.subjectsynaptic reorganizationen
dc.titleThe role of mossy cell death and activation of protein synthesis in the sprouting of dentate mossy fibers: Evidence from calretinin and neo-timm staining in pilocarpine-epileptic miceen
dc.typeinfo:eu-repo/semantics/article
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