Repetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disorders

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dc.contributor.authorClaudino, A. M. [UNIFESP]
dc.contributor.authorVan den Eynde, F.
dc.contributor.authorStahl, D.
dc.contributor.authorDew, T.
dc.contributor.authorAndiappan, M.
dc.contributor.authorKalthoff, J.
dc.contributor.authorSchmidt, U.
dc.contributor.authorCampbell, I. C.
dc.contributor.institutionKings Coll London
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionKings Coll NHS Trust
dc.date.accessioned2016-01-24T14:16:50Z
dc.date.available2016-01-24T14:16:50Z
dc.date.issued2011-06-01
dc.description.abstractBackground. in people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has a similar effect on salivary cortisol concentrations, a measure of hypothalamic-pituitary-adrenal axis (HPAA) activity.Method. We enrolled twenty-two female participants who took part in a double-blind randomized sham-controlled trial on the effects of rTMS on food craving. Per group, eleven participants were randomized to the real or sham rTMS condition. the intervention consisted of one session of high-frequency rTMS delivered to the left dorsolateral prefrontal cortex (DLPFC). Salivary cortisol concentrations were assessed at four time points throughout the 90-min trial. To investigate differences in post-rTMS concentrations between the real and sham rTMS groups, a random-effects model including the pre-rTMS cortisol concentrations as covariates was used.Results. Salivary cortisol concentrations following real rTMS were significantly lower compared with those following sham rTMS. in this sample, there was also a trend for real rTMS to reduce food craving more than sham rTMS.Conclusions. These results suggest that rTMS applied to the left DLPFC alters HPAA activity in people with a bulimic disorder.en
dc.description.affiliationKings Coll London, Inst Psychiat, Sect Eating Disorders, London SE5 8AF, England
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationKings Coll NHS Trust, Dept Chem Pathol, London, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipNational Institute for Health Research (NIHR) Specialist Biomedical Research Centre
dc.format.extent1329-1336
dc.identifierhttp://dx.doi.org/10.1017/S0033291710001881
dc.identifier.citationPsychological Medicine. New York: Cambridge Univ Press, v. 41, n. 6, p. 1329-1336, 2011.
dc.identifier.doi10.1017/S0033291710001881
dc.identifier.issn0033-2917
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33768
dc.identifier.wosWOS:000290221200021
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofPsychological Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectBinge eatingen
dc.subjectcravingen
dc.subjecteating disordersen
dc.subjecthypothalamic-pituitary-adrenal axisen
dc.subjectrepetitive transcranial magnetic stimulationen
dc.subjectsalivary cortisolen
dc.titleRepetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disordersen
dc.typeinfo:eu-repo/semantics/article
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