High-sensitivity c-reactive protein and cardiovascular disease across countries and ethnicities

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dc.contributor.authorHelfenstein Fonseca, Francisco Antonio [UNIFESP]
dc.contributor.authorde Oliveira Izar, Maria Cristina [UNIFESP]
dc.date.accessioned2019-01-21T10:29:56Z
dc.date.available2019-01-21T10:29:56Z
dc.date.issued2016
dc.description.abstractDespite substantial differences in ethnicities, habits, cultures, the prevalence of traditional cardiovascular risk factors and affordable therapies, atherosclerosis remains the major cause of death in developing and developed countries. However, irrespective of these differences, inflammation is currently recognized as the common pathway for the major complications of atherosclerosis, stroke, and ischemic heart disease. A PubMed search was conducted for "high-sensitivity C-reactive protein'' (hs-CRP) in combination with the terms race, ethnicity, gender, prevalence, geographic, epidemiology, cardiovascular, obesity, diabetes, hypertension, cholesterol, smoking, ischemic heart disease, stroke, and mortality. This review includes the articles that pertained to the topic and additional articles identified from the reference lists of relevant publications. This review describes the marked differences in cardiovascular mortality across countries and ethnicities, which may be attributed to inequalities in the prevalence of the classic risk factors and the stage of cardiovascular epidemiological transition. However, hs-CRP appears to contribute to the prognostic information regarding cardiovascular risk and mortality even after multiple adjustments. Considering the perception of cardiovascular disease as an inflammatory disease, the more widespread use of hs-CRP appears to represent a valid tool to identify people at risk, independent of their ancestry or geographic region. In conclusion, this review reports that the complications associated with vulnerable atherosclerotic plaques are triggered by the major mechanisms of dyslipidemia and inflammationen
dc.description.abstractwhereas both mechanisms are influenced by classic risk factors, hs-CRP contributes additional information regarding cardiovascular events and mortality.en
dc.description.affiliationUniversidade Federal de São Paulo, Departamento de Medicina, Divisão de Cardiologia, São Paulo/SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Medicina, Divisão de Cardiologia, São Paulo/SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent235-242
dc.identifierhttp://dx.doi.org/10.6061/clinics/2016(04)11
dc.identifier.citationClinics. Sao paulo, v. 71, n. 4, p. 235-242, 2016.
dc.identifier.doi10.6061/clinics/2016(04)11
dc.identifier.issn1807-5932
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49485
dc.identifier.wosWOS:000378142200011
dc.language.isoeng
dc.publisherHospital clinicas, univ sao paulo
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectC-Reactive Proteinen
dc.subjectEthnic Groupsen
dc.subjectRisk Factorsen
dc.subjectCardiovascular DiseaseDensity-Lipoprotein Cholesterolen
dc.subjectEvaluating Rosuvastatin Jupiteren
dc.subjectCoronary-Heart-Diseaseen
dc.subjectApparently Healthy-Menen
dc.subject14 Randomized-Trialsen
dc.subjectStatin Therapyen
dc.subjectIntervention Trialen
dc.subjectPrimary Preventionen
dc.subjectLdl Cholesterolen
dc.subjectGeneral-Populationen
dc.titleHigh-sensitivity c-reactive protein and cardiovascular disease across countries and ethnicitiesen
dc.typeinfo:eu-repo/semantics/review
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