Malaria vaccine: roadblocks and possible solutions

Página do item simplificado
dc.contributor.authorSoares, Irene da Silva [UNIFESP]
dc.contributor.authorRodrigues, Mauricio Martins [UNIFESP]
dc.contributor.institutionUniversidade Federal do Pará
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:43Z
dc.date.available2015-06-14T13:24:43Z
dc.date.issued1998-03-01
dc.description.abstractMalaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solveden
dc.description.affiliationUniversidade Federal do Pará
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, São Paulo, Brazil
dc.description.sourceSciELO
dc.format.extent317-332
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1998000300002
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 317-332, 1998.
dc.identifier.doi10.1590/S0100-879X1998000300002
dc.identifier.fileS0100-879X1998000300002.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1998000300002
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/601
dc.identifier.wosWOS:000073337200002
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmalariaen
dc.subjectPlasmodiumen
dc.subjectvaccineen
dc.subjectimmunityen
dc.subjectinfectious diseaseen
dc.titleMalaria vaccine: roadblocks and possible solutionsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X1998000300002.pdf
Tamanho:
88.61 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos