Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning

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dc.contributor.authorPerez Figueredo, Larissa Zeggio [UNIFESP]
dc.contributor.authorMoreira, Karin Monteiro [UNIFESP]
dc.contributor.authorFerreira, Tatiana Lima [UNIFESP]
dc.contributor.authorFornari, Raquel Vecchio [UNIFESP]
dc.contributor.authorMenezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:42Z
dc.date.available2016-01-24T13:51:42Z
dc.date.issued2008-09-30
dc.description.abstractA number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction has not been elucidated.The aim of this study was to determine whether the concomitant administration of MK-801 (noncompetitive NMDA antagonist) and dicyclomine (M1-muscarinic antagonist - DIC) in sub-effective doses impairs contextual fear conditioning (hippocampal-dependent task) and tone fear conditioning tasks (hippocampal-independent task).The results showed that concomitant pre-training administration of DIC (8.0 mg/kg) and MK-801 (0.07 mg/kg) - two sub-effectives doses for the contextual fear conditioning task - does impair the performance of animals on this task (as measured by freezing behavior time). Tone fear conditioning tasks were not affected by the drugs either administered separately or concurrently.The pre-training administration of sub-effective doses of MK-801 and DIC in combination impairs performance on contextual fear conditioning task (hippocampal-dependent), but not on tone fear conditioning task (hippocampal-independent). These data support the hypothesis that the interaction between glutamatergic and cholinergic systems in hippocampus-dependent learning and memory processes probably occurs through M1 receptor. (C) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipFADA
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent71-76
dc.identifierhttp://dx.doi.org/10.1016/j.brainresbull.2008.05.008
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 77, n. 2-3, p. 71-76, 2008.
dc.identifier.doi10.1016/j.brainresbull.2008.05.008
dc.identifier.issn0361-9230
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30911
dc.identifier.wosWOS:000259552900001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectlearning and memoryen
dc.subjectdicyclomineen
dc.subjectMK-801en
dc.subjectM1 receptoren
dc.subjecthippocampusen
dc.titleInteraction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioningen
dc.typeinfo:eu-repo/semantics/article
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