Espectroscopia por ressonância magnética de prótons em epilepsia mioclônica juvenil sugere o comprometimento de uma rede neuronal específica

Página do item simplificado
dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorLin, Jaime [UNIFESP]
dc.contributor.authorPeruchi, M.m. [UNIFESP]
dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorPascalicchio, T.f. [UNIFESP]
dc.contributor.authorGuaranha, Mirian Salvadori Bittar [UNIFESP]
dc.contributor.authorGuilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:38:42Z
dc.date.available2015-06-14T13:38:42Z
dc.date.issued2008-09-01
dc.description.abstractOBJECTIVES: The neuroanatomical basis and the neurochemical abnormalities that underlay juvenile myoclonic epilepsy (JME) are not fully defined. While the thalamus plays a central role in synchronization of widespread regions of the cerebral cortex during a seizure, emerging evidence suggests that all cortical neurons may not be homogeneously involved. The purpose of this study was to investigate the cerebral metabolic differences between patients with JME and normal controls. METHODS: All patients had a JME diagnosis based on seizure history and semiology, EEG recording, normal magnetic resonance neuroimaging (MRI) and video-EEG. Forty JME patients (JME-P) were submitted to 1.5 T MRI proton spectroscopy (1H-MRS), multi-voxel with PRESS sequence (TR/TE = 1500/30 ms) over the following locations: prefrontal cortex (PC), frontal cortex (FC), thalamus, basal nuclei, posterior cingulate gyrus (PCG), insular, parietal and occipital cortices. We determined ratios for integral values of N-acetyl aspartate (NAA) and glutamine-glutamate (GLX) over creatine-phosphocreatine (Cr). The control group (CTL) consisted of 20 age and sex-matched healthy volunteers. RESULTS: Group analysis demonstrated a tendency for lower NAA/Cr ratio of JME-P compared to CTL predominantly on FC, PC, thalamus and occipital cortex. When compared to CTL, JME-P had a statistically significant difference in GLX/Cr on FC, PC, insula, basal nuclei, PCG and on thalamus. When evaluating the relationship among the various components of this epileptic network among JME-P, the strongest correlation occurred between thalamus and PC. Also, we found a significant negative correlation between NAA/Cr and duration of epilepsy. CONCLUSION: Reductions in NAA may represent loss or injury of neurons and/or axons, as well as metabolic dysfunction while glutamate is considered to be an excitatory neurotransmitter in the brain which is involved in the pathogenesis of epileptogenic seizures.en
dc.description.affiliationUNIFESP-EPM Hospital São Paulo
dc.description.affiliationUnifespUNIFESP, EPM, Hospital São Paulo
dc.description.sourceSciELO
dc.format.extent99-100
dc.identifierhttp://dx.doi.org/10.1590/S1676-26492008000300003
dc.identifier.citationJournal of Epilepsy and Clinical Neurophysiology. Liga Brasileira de Epilepsia (LBE), v. 14, n. 3, p. 99-100, 2008.
dc.identifier.doi10.1590/S1676-26492008000300003
dc.identifier.fileS1676-26492008000300003.pdf
dc.identifier.issn1676-2649
dc.identifier.scieloS1676-26492008000300003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4538
dc.language.isopor
dc.publisherLiga Brasileira de Epilepsia (LBE)
dc.relation.ispartofJournal of Epilepsy and Clinical Neurophysiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectJuvenile myoclonic epilepsyen
dc.subjectmagnetic resonance spectroscopyen
dc.subjectmagnetic resonance imagingen
dc.subjectEpilepsia mioclônica juvenilpt
dc.subjectespectroscopia por ressonância magnéticapt
dc.subjectimagem por ressonância magnéticapt
dc.titleEspectroscopia por ressonância magnética de prótons em epilepsia mioclônica juvenil sugere o comprometimento de uma rede neuronal específicapt
dc.title.alternativeProton magnetic resonance spectroscopy study of juvenile myoclonic epilepsy patients suggests involvement of a specific neuronal networken
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1676-26492008000300003.pdf
Tamanho:
67.85 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos