Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

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dc.contributor.authorNegri, Giuseppina [UNIFESP]
dc.contributor.authorSanti, Daniel de [UNIFESP]
dc.contributor.authorTabach, Ricardo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:45:00Z
dc.date.available2015-06-14T13:45:00Z
dc.date.issued2012-10-01
dc.description.abstractSiparuna guianensis Aubl., Siparunaceae, is used as anxiolytic plants in folk medicine by South-American indians, caboclos and river-dwellers. This work focused the evaluation of phenolic composition of hydroethanolic extract of S. guianensis through HPLC-DAD-ESI/MS/MS. The constituents exhibited protonated, deprotonated and sodiated molecules and the MS/MS fragmentation of protonated, deprotonated and sodiated molecules provided product ions with rich structural information. Vicenin-2 (apigenin-6,8-di-C-glucoside) was the main constituent found in S. guianensis together quercetin-3,7-di-O-rhamnoside and kaempferol-3,7di-O-rhamnoside. A commercial extract of Passiflora incarnata (Phytomedicine) was used as surrogate standard and also was analyzed through HPLC-DAD-ESI/ MS/MS, showing flavones C-glycosides as constituents, among them, vicenin-2 and vitexin. The main constituent was vitexin. Flavonols triglycosides was also found in low content in S. guianensis and were tentatively characterized as quercetin-3O-rutinoside-7-O-rhamnoside, quercetin-3-O-pentosyl-pentoside-7-O-rhamnoside and kaempferol-3-O-pentosyl-pentoside-7-O-rhamnoside. Apigenin and kaempferol derivatives had been reported as anxiolytic agents. Flavonoids present in this extract were correlated with flavonoids reported as anxiolytics.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psicobiologia
dc.description.affiliationUnifespUNIFESP, Depto. de Psicobiologia
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.format.extent1024-1034
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2012005000034
dc.identifier.citationRevista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 5, p. 1024-1034, 2012.
dc.identifier.doi10.1590/S0102-695X2012005000034
dc.identifier.fileS0102-695X2012000500014.pdf
dc.identifier.issn0102-695X
dc.identifier.scieloS0102-695X2012000500014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7351
dc.identifier.wosWOS:000308948000013
dc.language.isoeng
dc.publisherSociedade Brasileira de Farmacognosia
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSiparuna guianensisen
dc.subjectPassiflora incarnataen
dc.subjectvitexinen
dc.subjectvicenin-2en
dc.subjectHPLC-DAD-ESI-MS/MSen
dc.subjectanxiolytic activityen
dc.titleChemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon regionen
dc.typeinfo:eu-repo/semantics/article
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