Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma

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dc.citation.issue4
dc.citation.volume123
dc.contributor.authorDiniz-Filho, Alberto
dc.contributor.authorAbe, Ricardo Y.
dc.contributor.authorCho, Hyong Jin
dc.contributor.authorBaig, Saif
dc.contributor.authorGracitelli, Carolina Pelegrini Barbosa [UNIFESP]
dc.contributor.authorMedeiros, Felipe A.
dc.coverageNew York
dc.date.accessioned2020-07-22T13:23:21Z
dc.date.available2020-07-22T13:23:21Z
dc.date.issued2016
dc.description.abstractPurpose: To evaluate the association between the rates of progressive visual field loss and the occurrence of depressive symptoms in patients with glaucoma followed over time. Design: Prospective observational cohort study. Participants: The study included 204 eyes of 102 patients with glaucomatous visual field defects on standard automated perimetry (SAP). Methods: All patients had Geriatric Depression Scale (GDS) questionnaires and visual field tests obtained over a mean follow-up time of 2.2 +/- 0.6 years. Change in depressive symptoms was assessed by calculating the difference between GDS scores at the last follow-up visit from those at baseline. Rates of visual field loss were assessed by SAP. An integrated binocular visual field was estimated from the monocular SAP tests, and rates of change in mean sensitivity (MS) over time were obtained from linear mixed models. Regression models were used to investigate the association between progressive visual field loss and changes in depressive symptoms, adjusting for potentially confounding clinical and socioeconomic variables. Main Outcome Measures: The association between rates of change in binocular SAP MS and change in GDS questionnaire scores. Results: There was a significant correlation between change in the GDS scores during follow-up and change in binocular SAP sensitivity. Each 1 decibel (dB)/year change in binocular SAP MS was associated with a change of 2.0 units in the GDS scores during the follow-up period (P = 0.025). In a multivariable model adjusting for baseline disease severity, change in visual acuity, age, gender, race, Montreal Cognitive Assessment score, education, income, and comorbidity index, each 1 dB/year change in binocular SAP MS was associated with a change of 3.0 units in the GDS score (P = 0.019). Conclusions: Faster visual field progression was associated with the occurrence of depressive symptoms in patients with glaucoma. (C) 2016 by the American Academy of Ophthalmology.en
dc.description.affiliationUniv Calif San Diego, Dept Ophthalmol, Lab Performance & Visual Funct, La Jolla, CA 92093 USA
dc.description.affiliationUniv Fed Minas Gerais, Dept Ophthalmol & Otorhinolaryngol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav,Cousins Ctr Psy, Los Angeles, CA 90095 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institutes of Health/National Eye Institute [EY021818, EY025056]
dc.description.sponsorshipResearch to Prevent Blindness (New York, NY) [P30EY022589]
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development (CNPq) [233829/2014-8]
dc.description.sponsorshipBrazilian National Research Council (CAPES) [12309-13-3]
dc.format.extent754-759
dc.identifierhttp://dx.doi.org/10.1016/j.ophtha.2015.12.014
dc.identifier.citationOphthalmology. New York, v. 123, n. 4, p. 754-759, 2016.
dc.identifier.doi10.1016/j.ophtha.2015.12.014
dc.identifier.issn0161-6420
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56196
dc.identifier.wosWOS:000372718300019
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofOphthalmology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleFast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucomaen
dc.typeinfo:eu-repo/semantics/article
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