Delayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat diet

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dc.contributor.authorGiriko, Catherine Assuka [UNIFESP]
dc.contributor.authorAndreoli, Carla Albuquerque [UNIFESP]
dc.contributor.authorMennitti, Lais Vales [UNIFESP]
dc.contributor.authorHosoume, Lilian Fazion [UNIFESP]
dc.contributor.authorSouto, Tayane dos Santos [UNIFESP]
dc.contributor.authorSilva, Alexandre Valotta da [UNIFESP]
dc.contributor.authorMendes-da-Silva, Cristiano [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:48Z
dc.date.available2016-01-24T14:34:48Z
dc.date.issued2013-12-01
dc.description.abstractEarly maternal exposure to a high-fat diet (HFD) may influence the brain development of rat offspring and consequently affect physiology and behavior. Thus, in the present study, we investigated the somatic, physical, sensory-motor and neurobehavioral development of the offspring of dams fed an HFD (52% calories from fat, mainly saturated) and the offspring of dams fed a control diet (CD - 14.7% fat) during lactation from the 1st to the 21st postnatal day (P). Maternal body weights were evaluated during lactation. in the progeny, somatic (body weight, head and lengths axes) and physical (ear unfolding, auditory conduit opening, eruption of the incisors and eye opening) development and the consolidation of reflex responses (palm grasp, righting, vibrissa placing, cliff avoidance, negative geotaxis, auditory startle response and free-fall righting) were determined during suckling. Depressive and aggressive behaviors were tested with the forced swimming test (FST) and the foot-shock test on days 60 and 110, respectively. the open field test was used to assess motor function. Compared to controls, the HFD-pups exhibited decreases in body weight (P7-P21) and body length (P4-P18), but by days P71 and P95, these pups were overweight. All indicators of physical maturation and the consolidation of the following reflexes, vibrissa placing, auditory startle responses, free-fall righting and negative geotaxis, were delayed in HFD-progeny. in addition, the pups from HFD dam rats also exhibited reduced swimming and climbing times in the FST and increased aggressive behavior. No changes in locomotion were observed. These findings show developmental and neurobehavioral changes in the rat offspring of dams fed the HFD during lactation and suggest possible disruption of physical and sensory-motor maturation and increased susceptibility to depressive and aggressive-like behavior. (C) 2013 ISDN. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, BR-11060001 Santos, Brazil
dc.description.affiliationInterdisciplinary Master Hlth Sci UNIFESP, BR-11060001 Santos, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, BR-11060001 Santos, Brazil
dc.description.affiliationUnifespInterdisciplinary Master Hlth Sci UNIFESP, BR-11060001 Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 11/17574-4
dc.description.sponsorshipIDFAPESP: 11/15329-2
dc.format.extent731-739
dc.identifierhttp://dx.doi.org/10.1016/j.ijdevneu.2013.09.001
dc.identifier.citationInternational Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier B.V., v. 31, n. 8, p. 731-739, 2013.
dc.identifier.doi10.1016/j.ijdevneu.2013.09.001
dc.identifier.issn0736-5748
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37038
dc.identifier.wosWOS:000329270200004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Developmental Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHigh-fat dieten
dc.subjectLactationen
dc.subjectPhysical growthen
dc.subjectReflex ontogenyen
dc.subjectOffspringen
dc.subjectDepressionen
dc.subjectAggressivenessen
dc.titleDelayed physical and neurobehavioral development and increased aggressive and depression-like behaviors in the rat offspring of dams fed a high-fat dieten
dc.typeinfo:eu-repo/semantics/article
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