Lactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parameters

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dc.contributor.authorRocha, Antonio Jose da
dc.contributor.authorBraga, Flavio Tulio
dc.contributor.authorMaia Junior, Antonio Carlos Martins [UNIFESP]
dc.contributor.authorSilva, Carlos Jorge da
dc.contributor.authorToyama, Carlos
dc.contributor.authorPinto Gama, Hugo Pereira
dc.contributor.authorKok, Fernando [UNIFESP]
dc.contributor.authorGomes, Helio Rodrigues [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFleury Diagnost Ctr
dc.date.accessioned2016-01-24T13:49:18Z
dc.date.available2016-01-24T13:49:18Z
dc.date.issued2008-01-01
dc.description.abstractMitochondriopathies are a heterogeneous group of diseases with variable phenotypic presentation, which can range from subclinical to lethal forms. They are related either to DNA mutations or nuclear-encoded mitochondrial genes that affect the integrity and function of these organelles, compromising adenosine triphosphate (ATP) synthesis. Magnetic resonance (MR) is the most important imaging technique to detect structural and metabolic brain abnormalities in mitochondriopathies, although in some cases these studies may present normal results, or the identified brain abnormalities may be nonspecific. Magnetic resonance spectroscopy (MRS) enables the detection of high cerebral lactate levels, even when the brain has normal appearance by conventional MR scans. MRS is a useful tool for the diagnosis of mitochondriopathies, but must be correlated with clinical, neurophysiological, biochemical, histological, and molecular data to corroborate the diagnosis. Our aim is to clarify the most relevant issues related to the use of MRS in order to optimize its technical parameters, improving its use in the diagnosis of mitochondriopathies, which is often a challenge.en
dc.description.affiliationSanta Casa São Paulo, Fac Med Sci, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.affiliationFleury Diagnost Ctr, Sect Innate Metab Disorders, São Paulo, Brazil
dc.description.affiliationFleury Diagnost Ctr, Sect Cerebrospinal Fluid, São Paulo, Brazil
dc.description.affiliationFleury Diagnost Ctr, Sect Radiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.1111/j.1552-6569.2007.00205.x
dc.identifier.citationJournal of Neuroimaging. Oxford: Blackwell Publishing, v. 18, n. 1, p. 1-8, 2008.
dc.identifier.doi10.1111/j.1552-6569.2007.00205.x
dc.identifier.issn1051-2284
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30235
dc.identifier.wosWOS:000252209600001
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Neuroimaging
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmitochondrial disordersen
dc.subjectlactateen
dc.subjectmagnetic resonance spectroscopyen
dc.titleLactate detection by MRS in mitochondrial encephalopathy: Optimization of technical parametersen
dc.typeinfo:eu-repo/semantics/article
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