Pregnancy after renal transplantation - a five-yr single-center experience
| dc.contributor.author | Oliveira, Leandro G. | |
| dc.contributor.author | Sass, Nelson | |
| dc.contributor.author | Sato, Jussara L. | |
| dc.contributor.author | Ozaki, Kikumi S. | |
| dc.contributor.author | Medina Pestana, Jose O. | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T13:48:42Z | |
| dc.date.available | 2016-01-24T13:48:42Z | |
| dc.date.issued | 2007-05-01 | |
| dc.description.abstract | Background: There has been an increase in the number of pregnancies in renal transplant recipients. Our aim was to report our experience with a significant casuistic.Methods: Fifty-two pregnancies in 52 patients (January 2001 to December 2005), with two patients having a multiple pregnancy, were evaluated and patients were characterized and evaluated as clinical and obstetrical and perinatal outcomes.Results: Mean patient age was 26.5 yr (range 17-38) with live donors in 34 (65.4%) and cadaver donors in 18 (34.6%). the mean transplantation-pregnancy interval was 3.1 yr. Calcineurin inhibitors (cyclosporine or tacrolimus) comprised the immunosuppressive therapy in 49 pregnancies (94.2%). Pregnancy complications were chronic hypertension in 33 patients (63.5%), anemia in 31 (59.6%), urinary tract infection in 22 (42.3%) and diabetes in four (7.7%). Nine patients (17.3%) received blood transfusion. Preeclampsia was diagnosed in 16 cases (30.7%) and renal dysfunction in 23 (44.2%) with preeclampsia assumed to be the main cause. One patient (1.9%) had graft loss, as a result of hemorrhagic shock after preterm delivery at home. Premature rupture of membranes occurred in four cases (7.7%), and preterm delivery in 20 (38.4%). Sixteen (29.6%) newborn were small for gestational age. One case of neonatal death was registered as a result of excessive prematurity. Cesarean section was performed in 32 patients (61.5%), the main indications being related to hypertension syndromes and fetal distress.Conclusions: This group of patients is characterized by a wide range of antenatal and perinatal problems and must be managed in specialized tertiary units to achieve the very best results. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil | |
| dc.description.affiliation | Universidade Federal de São Paulo, Nephrol Div Renal Transplant, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Nephrol Div Renal Transplant, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 301-304 | |
| dc.identifier | http://dx.doi.org/10.1111/j.1399-0012.2006.00627.x | |
| dc.identifier.citation | Clinical Transplantation. Oxford: Blackwell Publishing, v. 21, n. 3, p. 301-304, 2007. | |
| dc.identifier.doi | 10.1111/j.1399-0012.2006.00627.x | |
| dc.identifier.issn | 0902-0063 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/29735 | |
| dc.identifier.wos | WOS:000246151700002 | |
| dc.language.iso | eng | |
| dc.publisher | Blackwell Publishing | |
| dc.relation.ispartof | Clinical Transplantation | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.subject | immunosuppressive therapy | en |
| dc.subject | preeclampsia | en |
| dc.subject | pregnancy | en |
| dc.subject | renal transplant | en |
| dc.title | Pregnancy after renal transplantation - a five-yr single-center experience | en |
| dc.type | info:eu-repo/semantics/article |