MPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosis

Página do item simplificado
dc.contributor.authorPonce, Cesar Cilento [UNIFESP]
dc.contributor.authorChauffaille, Maria de Lourdes F. [UNIFESP]
dc.contributor.authorIhara, Silvia Saiuli M. [UNIFESP]
dc.contributor.authorSilva, Maria Regina R. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:43Z
dc.date.available2016-01-24T14:17:43Z
dc.date.issued2012-01-01
dc.description.abstractTo evaluate the grading of fibrosis and immunohistochemical expression of MPL in bone marrow biopsies of ET and PMF. Fibrosis in bone marrow biopsies (BMBs) was evaluated according to the European Consensus for grading of fibrosis, according to reticulin proliferation. Immunohistochemical analysis was performed in samples from 18 ET and 38 PMF patients: 19 were classified as pre-fibrotic and 19 were classified as fibrotic according to the World Health Organization (WHO) criteria, by means of the MPL antibody. Six bone marrow donors' biopsies were used as controls. Average reticulin (p < 0.003) and MPL (p < 0.008) values differed significantly between the ET group and the pre-fibrotic stage PMF group. the MPL immunohistochemical expression may represent a new marker for differential diagnosis between ET and pre-fibrotic stage PMF. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 07-55948-8
dc.format.extent93-97
dc.identifierhttp://dx.doi.org/10.1016/j.leukres.2011.06.024
dc.identifier.citationLeukemia Research. Oxford: Pergamon-Elsevier B.V., v. 36, n. 1, p. 93-97, 2012.
dc.identifier.doi10.1016/j.leukres.2011.06.024
dc.identifier.issn0145-2126
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34456
dc.identifier.wosWOS:000298149100034
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLeukemia Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectThrombopoietin receptor (MPL)en
dc.subjectMegakaryocytesen
dc.subjectPrimary myelofibrosisen
dc.subjectEssential thrombocythemiaen
dc.subjectImmunohistochemistryen
dc.subjectFibrosisen
dc.titleMPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosisen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos