Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury
| dc.contributor.author | Murad, Neif [UNIFESP] | |
| dc.contributor.author | Takiuchi, Katia [UNIFESP] | |
| dc.contributor.author | Lopes, Antonio C. [UNIFESP] | |
| dc.contributor.author | Bonilha, André MM [UNIFESP] | |
| dc.contributor.author | Souza, Marcio M. [UNIFESP] | |
| dc.contributor.author | Demarchi, Lea Maria MF | |
| dc.contributor.author | Higuchi, Maria de Lourdes | |
| dc.contributor.author | Tucci, Paulo JF [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.contributor.institution | Universidade de São Paulo (USP) | |
| dc.date.accessioned | 2016-01-24T12:31:22Z | |
| dc.date.available | 2016-01-24T12:31:22Z | |
| dc.date.issued | 2001-05-01 | |
| dc.description.abstract | The influence of coenzyme Q(10) (CoQ(10)) in cold stress test (-15 degreesC for 4 hours) cardiac functional impairment was studied in isolated isovolumic heart of control rats (C; n=12) and of placebo (P; n=11) and treated rats (CoQ(10); n=10). in addition, electron microscopic evaluation of left ventricular (LV) slices (n=3 in each group) allowed us to analyze the myocardial ultrastructure. Maximal values of developed pressure (DPmax) were similarly decreased in cold stressed animals (C=129 +/-3.9 mmHg; P=106 +/-6.7 mmHg; CoQ(10)=91 +/-3.9 mmHg); however, volume-induced enhancement of pressure generation (slope of DP / volume relations: C=0.248 +/-0.0203 mmHg/mul; P=0.2831 +/-0.0187 mmHg/mul; CoQ(10)=0.2387 (0.0225 mmHg/mul; p >0.05), and the duration of systole (C=80 +/- .6 ms; P=78 +/-1.3 ms; CoQ(10) = 80 +/-2.7 ms) were not altered. Myocardial relaxation, evaluated by the relaxation constant (C=39 +/-1.9 ins; P=42 +/-3.4 ms; CoQ(10)=51 +/-6.0 ms), as well as resting stress / strain relations were unaffected by cold stress. Myocardial samples showed that pretreatment with CoQ(10) attenuates myofibrillar and mitochondrial lesions, and prevents mitochondrial fractional area increase (P: 53.11%> CoQ(10): 38.78%=C: 33.87%; p <0.005) indicating that the exogenous administration of CoQ(10) can reduce cold stress myocardial injury. | en |
| dc.description.affiliation | Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil | |
| dc.description.affiliation | Univ São Paulo, Inst Coracao, São Paulo, Brazil | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 327-338 | |
| dc.identifier | http://dx.doi.org/10.1536/jhj.42.327 | |
| dc.identifier.citation | Japanese Heart Journal. Tokyo: Japan Heart Journal, Second Dept of Internal Med, v. 42, n. 3, p. 327-338, 2001. | |
| dc.identifier.doi | 10.1536/jhj.42.327 | |
| dc.identifier.issn | 0021-4868 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/26537 | |
| dc.identifier.wos | WOS:000171471700007 | |
| dc.language.iso | eng | |
| dc.publisher | Japan Heart Journal, Second Dept of Internal Med | |
| dc.relation.ispartof | Japanese Heart Journal | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | ubiquinone | en |
| dc.subject | coenzyme Q(10) | en |
| dc.subject | cold stress test | en |
| dc.subject | systolic function | en |
| dc.subject | diastolic | en |
| dc.subject | function | en |
| dc.title | Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury | en |
| dc.type | info:eu-repo/semantics/article |