A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

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dc.citation.issue8
dc.citation.volume171
dc.contributor.authorSantoro, Marcos Leite [UNIFESP]
dc.contributor.authorMoretti, Patricia N. [UNIFESP]
dc.contributor.authorPellegrino, Renata
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.authorHayashi, Mirian Akemi Furuie [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.authorHakonarson, Hakon
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:08Z
dc.date.available2020-07-31T12:47:08Z
dc.date.issued2016
dc.description.abstractIn the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. (C) 2016 Wiley Periodicals, Inc.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Div Genet, Sao Paulo, SP, Brazil
dc.description.affiliationChildrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespInterdisciplinary Laboratory of Clinical Neurosciences, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Brazil
dc.description.affiliationUnifespDepartment of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Brazil
dc.description.affiliationUnifespGenetics Division, Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Brazil.
dc.description.affiliationUnifespDepartment of Pharmacology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipY-Mind Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDY-Mind FAPESP: 12/50316-1
dc.format.extent997-1005
dc.identifierhttp://dx.doi.org/10.1002/ajmg.b.32475
dc.identifier.citationAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. Hoboken, v. 171, n. 8, p. 997-1005, 2016.
dc.identifier.doi10.1002/ajmg.b.32475
dc.identifier.issn1552-4841
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56618
dc.identifier.wosWOS:000390663500024
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectGWASen
dc.subjectpsychiatryen
dc.subjectpolygenic risk scoreen
dc.subjectpsychiatric disorderen
dc.titleA Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disordersen
dc.typeinfo:eu-repo/semantics/article
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