Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood

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dc.contributor.authorSantos, Gabriela C.
dc.contributor.authorMarin, Marcelo T.
dc.contributor.authorCruz, Fabio Cardoso [UNIFESP]
dc.contributor.authorDeLucia, Roberto
dc.contributor.authorPlaneta, Cleopatra S.
dc.contributor.institutionUNESP São Paulo State Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:58:31Z
dc.date.available2016-01-24T13:58:31Z
dc.date.issued2009-07-01
dc.description.abstractNicotine and psychostimulants are often abused in combination and drug abuse often begins during adolescence and can have long-term consequences. Behavioral sensitization has been suggested as an animal model of neuroplasticity implicated in the development of drug addiction. We evaluated whether the pretreatment with nicotine (0.4 mg/kg; s.c.) or amphetamine (5.0 mg/kg: i.p.) in adolescent rats [from postnatal day (P) 28 to P34] could induce cross-sensitization to nicotine and amphetamine when animals were challenged during both adolescence (P37) and adulthood (P70), in separate groups of animals. Adolescent animals pretreated with amphetamine displayed behavioral sensitization to nicotine. which persisted until adulthood. Moreover. adolescent animals pretreated with nicotine showed sensitized locomotor response to amphetamine in the adulthood. These data suggest that adolescents who abuse nicotine may be particularly susceptible to the effects of amphetamine and vice versa. Moreover. this increased vulnerability may persist through their development until adulthood.en
dc.description.affiliationUNESP São Paulo State Univ, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Grad Program Physiol Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Lab Psychopharmal, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Grad Program Physiol Sci, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estaclo de São Paulo
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFundacao de Amparo a Pesquisa do Estaclo de São Paulo: FAPESP-97/11010-2
dc.format.extent270-275
dc.identifierhttp://dx.doi.org/10.1111/j.1369-1600.2009.00153.x
dc.identifier.citationAddiction Biology. Malden: Wiley-Blackwell Publishing, Inc, v. 14, n. 3, p. 270-275, 2009.
dc.identifier.doi10.1111/j.1369-1600.2009.00153.x
dc.identifier.issn1355-6215
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31666
dc.identifier.wosWOS:000268180100004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAddiction Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectAdolescenceen
dc.subjectamphetamineen
dc.subjectbehavioral sensitizationen
dc.subjectdrug addictionen
dc.subjectlocomotionen
dc.subjectnicotineen
dc.titleAmphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthooden
dc.typeinfo:eu-repo/semantics/article
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