The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids

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dc.contributor.authorGomes, Mariano Tamura Vieira [UNIFESP]
dc.contributor.authorCastro, Rodrigo de Aquino [UNIFESP]
dc.contributor.authorVillanova, Fabiola Elizabeth [UNIFESP]
dc.contributor.authorSilva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.authorGirão, Manoel João Batista Castello [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:48:36Z
dc.date.available2016-01-24T13:48:36Z
dc.date.issued2007-05-01
dc.description.abstractObjective: To assess the possible association between the polymorphic allele of the progesterone receptor gene, named PROGINS, and uterine leiomyomas.Design: Case-control study.Setting: Department of Gynecology. Teaching hospital.Patient(s): One hundred twenty-two premenopausal women with fibroids and 125 postmenopausal controls not presenting the disease.Intervention(s): the subjects were classified as White or non-White (Black and Mulatto) and the progesterone receptor genotyping was performed, with DNA extracted from uterus in cases and from peripheric blood in controls and submitted to polymerase chain reaction (PCR) and agarose gel electrophoresis.Main Outcome Measure(s): the presence of the PROGINS allele was recorded, and its frequency as well as the genotypic distribution among cases and controls were compared according to race.Result(s): PROGINS-positive genotypes (heterozygous or mutant homozygous) were found in 19% of White and 11% of non-White women, and allelic frequency of PROGINS in the groups was 10.4% and 6.2%, respectively. Comparing patients and controls, we observed a significant difference among non-White women, both regarding presence of PROGINS-positive genotypes (4.9% vs. 25%, respectively), and PROGINS allele frequency (3.3% vs. 12.5%, respectively). There was no significant difference in PROGINS-positive genotypes among White cases and controls (16.4% vs. 20.6%, respectively), and in their allelic frequency (8.2% vs. 11.9%, respectively). the odds ratio showed reduced risk of fibroids related to PROGINS-positive genotypes in non-White women (odds ratio = 0.16, 95% confidence interval: 0.04-0.66), but not among White subjects (odds ratio = 0.76, 95% confidence interval: 0.33-1.74).Conclusion(s): the PROGINS polymorphism revealed to be protective in terms of uterine fibroids in Brazilian non-White women.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1116-1121
dc.identifierhttp://dx.doi.org/10.1016/j.fertnstert.2006.08.099
dc.identifier.citationFertility and Sterility. New York: Elsevier B.V., v. 87, n. 5, p. 1116-1121, 2007.
dc.identifier.doi10.1016/j.fertnstert.2006.08.099
dc.identifier.issn0015-0282
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29677
dc.identifier.wosWOS:000246583600018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFertility and Sterility
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectuterine fibroidsen
dc.subjectuterine leiomyomaen
dc.subjectrisk factorsen
dc.subjectsexual steroids receptorsen
dc.subjectprogesterone receptoren
dc.subjectpolymorphismen
dc.subjectPROGINSen
dc.titleThe progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroidsen
dc.typeinfo:eu-repo/semantics/article
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