Assessment of Nutritional Status: Vitamin A and Zinc in Patients With Common Variable Immunodeficiency

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dc.contributor.authorCalheiro dos Santos-Valente, E. [UNIFESP]
dc.contributor.authorSilva, R. da [UNIFESP]
dc.contributor.authorMoraes-Pinto, M. I. de [UNIFESP]
dc.contributor.authorOselka Saccardo Sarni, R. [UNIFESP]
dc.contributor.authorCosta-Carvalho, B. T. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Alfenas
dc.contributor.institutionABC Univ
dc.date.accessioned2018-06-15T18:02:41Z
dc.date.available2018-06-15T18:02:41Z
dc.date.issued2012-01-01
dc.description.abstractBackground: Patients with common variable immunodeficiency (CVID) present with low antibody levels, impaired lymphocyte function, and chronic inflammation. Vitamin A and zinc are essential components of the immune system and can be redistributed in the body as a result of inflammation.Objective: To compare levels of retinol, beta-carotene, and zinc in patients with CVID and healthy controls after evaluating a series of parameters for each participant.Patients and Methods: We performed a cross-sectional study of CVID patients and healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising a complete blood count and determination of levels of C-reactive protein (CRP), lipopolysaccharide (LPS), soluble CD14 (sCD14), retinol, beta-carotene, and serum and erythrocyte zinc.Results: We included 17 patients (mean age, 28.54 years) and 17 controls. Mean (SD) retinol levels were lower in patients: 1.99 (0.67) mu mol/L vs 2.72 (0.96) mu mol/L. Median beta-carotene levels were similar in both groups (0.30 mu mol/L). Median serum zinc levels were 50.0 mu g/dL (50-100 mu g/dL) in the patients and 100.0 mu g/dL (50-150 mu g/dL) in the controls. Mean levels of erythrocyte zinc were lower among patients: 37.32 (10.51) mu gZn/gHb vs 44.91 (7.67) mu gZn/gHb in the controls. Median CRP levels were significantly higher among patients: 4.99 (0.15-34.51) mg/L vs 0.55 (0.17-6.06) mg/L. No differences in translocation marker levels were observed between the groups.Conclusions: CVID patients had lower levels of retinol and zinc than controls. Since micronutrient deficiency could aggravate their disease and contribute to chronic inflammation, micronutrient status should always be assessed in patients with primary immunodeficiency.en
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Alfenas, Alfenas, MG, Brazil
dc.description.affiliationABC Univ, Santo Andre, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 10109-1/2008
dc.format.extent427-431
dc.identifierhttp://www.jiaci.org/summary/vol22-issue6-num916
dc.identifier.citationJournal Of Investigational Allergology And Clinical Immunology. Barcelona: Esmon Publicidad S A, v. 22, n. 6, p. 427-431, 2012.
dc.identifier.issn1018-9068
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44458
dc.identifier.wosWOS:000311471100006
dc.language.isoeng
dc.publisherEsmon Publicidad S A
dc.relation.ispartofJournal Of Investigational Allergology And Clinical Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibody deficiencyen
dc.subjectNutritionen
dc.subjectVitamin Aen
dc.subjectZincen
dc.subjectBacterial translocationen
dc.titleAssessment of Nutritional Status: Vitamin A and Zinc in Patients With Common Variable Immunodeficiencyen
dc.typeinfo:eu-repo/semantics/article
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