Omega-3 levels and nicotine dependence: a cross-sectional study and clinical trial

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dc.contributor.authorZaparoli, Jucara X. [UNIFESP]
dc.contributor.authorSugawara, Eduardo K. [UNIFESP]
dc.contributor.authorde Souza, Altay A. L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorGalduroz, Jose Carlos F. [UNIFESP]
dc.date.accessioned2019-01-21T10:30:01Z
dc.date.available2019-01-21T10:30:01Z
dc.date.issued2016
dc.description.abstractBackground: High oxidative stress, which is caused by smoking, can alter omega-3 fatty acid concentrations. Since omega-3 fatty acids play a role in dopaminergic neurotransmission related to dependence, it is important to understand their effects on nicotine dependence. Methods: This research comprised 2 studies. The first one consisted of a cross-sectional evaluation, in which the levels of the most important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were compared between smokers and non-smokers in a sample of 171 individualsen
dc.description.abstractof them, 120 were smokers and 51 were non-smokers. The other study was a clinical, double-blind, randomized, placebo controlled, in which 63 smokers received daily treatment with capsules of fish oil (a source of omega-3/3 g/day) or mineral oil (used as placebo, also 3 g/day), taken 3 times a day for 90 days. Each fish oil capsules contained approximately 210.99 mg EPA and 129.84 mg of DHA. The outcome was evaluated by means of psychometric and biological measures as well as self-reports of tobacco use. The evaluations were carried out at the beginning of treatment and once a month thereafter (total of 4 times). Outcomes: The omega-3 fatty acid lipid profile showed that smokers present lower concentrations of DHA. After treatment, the omega-3 group showed a significant reduction in their levels of dependence. Interpretation: Smokers showed lower peripheral levels of omega-3, and treatment with the most important omega-3 fatty acids brought about a reduction in nicotine dependence. (C) 2015 S. Karger AG, Baselen
dc.description.affiliationDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPQ
dc.description.sponsorshipFAPESP [2012/06731-4, 2015/17708-1]
dc.description.sponsorshipAFIP
dc.description.sponsorshipCAPES
dc.description.sponsorshipIDCNPQ, FAPESP (#2012/06731-4 and #2015/17708-1), AFIP, CAPES.
dc.format.extent153-162
dc.identifierhttps://doi.org/10.1159/000439525
dc.identifier.citationEuropean Addiction Research. Basel, v. 22, n. 3, p. 153-162, 2016.
dc.identifier.doi10.1159/000439525
dc.identifier.issn1022-6877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49542
dc.identifier.wosWOS:000373925500005
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofEuropean Addiction Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectClinical Trialen
dc.subjectCross-Sectional Studyen
dc.subjectSmokingen
dc.subjectTobaccoen
dc.subjectOmega-3en
dc.subjectEpaen
dc.subjectDocosahexaenoic AcidEssential Fatty-Acidsen
dc.subjectRat Frontal-Cortexen
dc.subjectLipid-Peroxidationen
dc.subjectCocaine Addictionen
dc.subjectCigarette-Smokingen
dc.subjectOxidative Stressen
dc.subjectTobacco Smokingen
dc.subjectMetabolismen
dc.subjectSmokersen
dc.subjectOmega-3-Fatty-Acidsen
dc.titleOmega-3 levels and nicotine dependence: a cross-sectional study and clinical trialen
dc.typeinfo:eu-repo/semantics/article
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