Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal

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dc.contributor.authorAlves-Amaral, Gracielle [UNIFESP]
dc.contributor.authorPires-Oliveira, Marcelo [UNIFESP]
dc.contributor.authorAndrade-Lopes, Ana Luiza [UNIFESP]
dc.contributor.authorChiavegatti, Tiago [UNIFESP]
dc.contributor.authorGodinho, Rosely Oliveira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:47Z
dc.date.available2016-01-24T13:59:47Z
dc.date.issued2010-06-07
dc.description.abstractThe role of acetylcholinesterase (AChE) in the termination of the cholinergic response through acetylcholine (ACh) hydrolysis and the involvement of plasma butyrylcholinesterase (BuChE), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. Besides, BuChE has a crucial role in ACh hydrolysis, especially when selective anticholinesterases inhibit AChE. Herein, we analyzed the gender-related differences and the circadian changes of rat plasma cholinesterases. Plasma and liver cholinesterase activities were evaluated in control or 2-30-day castrated adult male and female rats. Plasma and liver AChE activities did not differ between genders and were not influenced by sex hormone deprivation. BuChE plasma activity was 7 times greater in female, reflecting gender differences in liver enzyme expression. Castration increased liver and plasma BuChE activity in male, while reduced it in female, abolishing gender differences in enzyme activity. Interestingly, female AChE and BuChE plasma activities varied throughout the day, reaching values 27% and 42% lower, respectively, between 2 p.m. and 6 p.m. when compared to the morning peaks at 8 a.m. Castration attenuated daily female BuChE oscillation. On the other hand, male plasma enzymes remained constant throughout the day. in summary, our results show that liver and plasma BuChE, but not AChE, expression is influenced by sex hormones, leading to high levels of blood BuChE in females. the fluctuation of female plasma BuChE during the day should be taken into account to adjust the bioavailability and the therapeutic effects of cholinesterase inhibitors used in cholinergic-based conditions such Alzheimer's disease. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol INFAR, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol INFAR, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 05/59006-1
dc.format.extent9-15
dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2010.04.002
dc.identifier.citationChemico-biological Interactions. Clare: Elsevier B.V., v. 186, n. 1, p. 9-15, 2010.
dc.identifier.doi10.1016/j.cbi.2010.04.002
dc.identifier.issn0009-2797
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32624
dc.identifier.wosWOS:000278801500002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofChemico-biological Interactions
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAcetylcholinesteraseen
dc.subjectButyrylcholinesteraseen
dc.subjectSex hormonesen
dc.subjectCircadian cycleen
dc.subjectBlooden
dc.titleGender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawalen
dc.typeinfo:eu-repo/semantics/article
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