Effects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in rats

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dc.contributor.authorFornari, Raquel V. [UNIFESP]
dc.contributor.authorSoares, Juliana C. K. [UNIFESP]
dc.contributor.authorFerreira, Tatiana L. [UNIFESP]
dc.contributor.authorMoreira, Karin M. [UNIFESP]
dc.contributor.authorOliveira, Maria G. M. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:33Z
dc.date.available2016-01-24T13:49:33Z
dc.date.issued2008-02-01
dc.description.abstractNociceptin, or orphanin FQ (N/OFQ), the endogenous ligand of NOP receptors, is known to regulate learning and memory processes. To verify the role of N/OFQ in the acquisition of contextual (CFC) and tone fear conditioning (TFC), Wistar male rats received intracerebroventricular injections of N/OFQ (0.1-5.0 nmol) before training, and were tested 24 and 48 hr later to access the freezing response to context and tone, respectively. the intermediate doses (1.0 and 2.5 nmol) impaired the CFC test, sparing TFC. the highest dose (5.0 nmol) reduced freezing during both tests, a result that may be due to nonspecific effects. the posttraining injection of N/OFQ (1 or 5 nmol) did not interfere with CFC and TFC, suggesting a specific effect of the peptide in acquisition processes. Moreover, the impairment observed with N/OFQ (1 nmol) in CFC cannot be attributed to a state-dependent learning because it was not reversed by its pretest administration. the data support the negative role of N/OFQ in the acquisition of aversively motivated tasks, which encompass a spatial component and depend on the hippocampus.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent98-106
dc.identifierhttp://dx.doi.org/10.1037/0735-7044.122.1.98
dc.identifier.citationBehavioral Neuroscience. Washington: Amer Psychological Assoc, v. 122, n. 1, p. 98-106, 2008.
dc.identifier.doi10.1037/0735-7044.122.1.98
dc.identifier.issn0735-7044
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30434
dc.identifier.wosWOS:000253332700011
dc.language.isoeng
dc.publisherAmer Psychological Assoc
dc.relation.ispartofBehavioral Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectN/OFQen
dc.subjectfear conditioningen
dc.subjectemotional memoryen
dc.subjecthippocampusen
dc.subjectopioiden
dc.titleEffects of nociceptin/orphanin FQ in the acquisition of contextual and tone fear conditioning in ratsen
dc.typeinfo:eu-repo/semantics/article
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