Addition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPD

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dc.contributor.authorCanto, Nívea Dias do
dc.contributor.authorRibeiro, Jorge Pinto
dc.contributor.authorNeder, José Alberto [UNIFESP]
dc.contributor.authorChiappa, Gaspar Rogério da
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniv So Santa Catarina
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:44Z
dc.date.available2016-01-24T14:27:44Z
dc.date.issued2012-10-01
dc.description.abstractBackground: the addition of tiotropium bromide (110) to formoterol fumarate (FOR) improves exercise performance in patients with chronic obstructive pulmonary disease (COPD). in this study, we test the hypothesis that the addition of TIO to for may improve respiratory muscle performance and oxygen uptake kinetics after exercise in patients with COPD.Methods: Thirty eight patients with COPD were randomized to a 2 week treatment with for 12 mu g twice a day plus TIO 18 mu g once a day (FOR + TIO) or for 12 mu g twice a day plus placebo (FOR + PLA) once a day, using a double-blind crossover design. Inspiratory muscle. Strength was measured before, immediately after, as well as 2, 5, and 10 min during recovery of exercise. Time to limit of tolerance on a constant work load exercise test and oxygen uptake kinetics during recovery were evaluated before and after intervention.Results: Only for + TIO improved resting (63 +/- 10 cm to 84 +/- 11 cmH(2)O) and post-exercise (49 +/- 7 cm to 84 +/- 11 cmH(2)O) maximal inspiratory pressure. Time to limit of tolerance on the constant work load test was increased by for + PLA and by for + TIO, but the size of the increment was significantly larger with for + TIO (40.7 +/- 7.6% vs. 84.5 +/- 8.2%; p < 0.05). Only for + TIO improved oxygen uptake kinetics during recovery (69 +/- 21 to 60 +/- 18s). the improvement in maximal inspiratory pressure (0.78, p < 0.001) and in oxygen uptake kinetics (-0.91, p < 0.001) correlated with the change in time to the limit of tolerance.Conclusions: the addition of TIO to for improves inspiratory muscle strength and oxygen uptake kinetics after exercise in COPD patients. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationHosp Clin Porto Alegre, Exercise Pathophysiol Res Lab, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Div Cardiol, Porto Alegre, RS, Brazil
dc.description.affiliationUniv So Santa Catarina, Exercise Biochem & Physiol Lab, Postgrad Program Hlth Sci, Hlth Sci Unit, Criciuma, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Med, Fac Med, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp, Dept Med, São Paulo, Brazil
dc.description.affiliationPaulista Sch Med UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespPaulista Sch Med UNIFESP EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1404-1412
dc.identifierhttp://dx.doi.org/10.1016/j.rmed.2012.05.012
dc.identifier.citationRespiratory Medicine. London: W B Saunders Co Ltd, v. 106, n. 10, p. 1404-1412, 2012.
dc.identifier.doi10.1016/j.rmed.2012.05.012
dc.identifier.fileWOS000309147400008.pdf
dc.identifier.issn0954-6111
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35301
dc.identifier.wosWOS:000309147400008
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofRespiratory Medicine
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRespiratory musclesen
dc.subjectOxygenen
dc.subjectInspiratory muscle strengthen
dc.subjectConstant work testen
dc.titleAddition of tiotropium to formoterol improves inspiratory muscle strength after exercise in COPDen
dc.typeinfo:eu-repo/semantics/article
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