Fear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatum

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dc.contributor.authorSchenberg, E. E.
dc.contributor.authorFerreira, T. L.
dc.contributor.authorFigueredo, L. Z.
dc.contributor.authorHipolide, D. C.
dc.contributor.authorNobrega, J. N.
dc.contributor.authorOliveira, MGM
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Addict & Mental Hlth
dc.date.accessioned2016-01-24T12:41:07Z
dc.date.available2016-01-24T12:41:07Z
dc.date.issued2006-04-28
dc.description.abstractWhile considerable evidence implicates NMDA receptors in the hippocampus in contextual fear conditioning, the role of other brain regions is less well understood. To further investigate this issue, rats were subjected to a contextual fear conditioning task and then classified as high or low responders according to performance. Density of NMDA receptors was evaluated using [H-3]MK-801 autoradiography in 52 brain areas and expression of NR2A and NR2B subunits was studied with in situ hybridization in the same brains. Results revealed no differences between high- and low-performance rats in NMDA receptor binding in any of the brain areas studied. Similarly, NR2B subunit expression was also not different between groups. However, NR2A expression was significantly higher in the caudate-putamen of low-performance rats. These results suggest that NMDA receptors in the caudate-putamen may also be involved in contextual fear conditioning performance. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationCtr Addict & Mental Hlth, Toronto, ON, Canada
dc.description.affiliationUnifespUNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent440-446
dc.identifierhttp://dx.doi.org/10.1016/j.brainresbull.2006.02.010
dc.identifier.citationBrain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 69, n. 4, p. 440-446, 2006.
dc.identifier.doi10.1016/j.brainresbull.2006.02.010
dc.identifier.issn0361-9230
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28852
dc.identifier.wosWOS:000237361500011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research Bulletin
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectbindingen
dc.subjectfear conditioningen
dc.subjectin situ hybridizationen
dc.subject[H-3]MK-801en
dc.subjectNMDAen
dc.subjectNR2Aen
dc.subjectNR2Ben
dc.titleFear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatumen
dc.typeinfo:eu-repo/semantics/article
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