Evaluation of renal function and immune system cells in elderly individuals from São Paulo City

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dc.contributor.authorTeixeira, Daniela [UNIFESP]
dc.contributor.authorLongo-Maugéri, Ieda Maria [UNIFESP]
dc.contributor.authorDuarte, Yeda Aparecida Oliveira
dc.contributor.authorLebrão, Maria Lucia
dc.contributor.authorBueno, Valquiria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversity of São Paulo Epidemiology Department
dc.date.accessioned2015-06-14T13:45:15Z
dc.date.available2015-06-14T13:45:15Z
dc.date.issued2013-01-01
dc.description.abstractOBJECTIVES: Both renal function and immune system function decline with age. Although controversial, a significant number of studies have shown that the decline in kidney function is associated with the worsening of the immune system. These findings are reinforced by the increased susceptibility to infections and deficient immunization coverage after vaccination both in patients with chronic renal disease and in elderly individuals. Our objective was to evaluate a non-institutionalized elderly population from São Paulo City and correlate the estimated glomerular filtration rate with the percentage of lymphocytes in circulation. METHODS: A random population of 237 individuals (107 men and 130 women), ranging in age from 60 to 101 years, who were enrolled in the Health, Well-Being and Aging Study was evaluated for renal function (Modification on Diet in Renal Disease formula) and lymphocyte percentage (flow cytometry). RESULTS: Aging was associated with a decrease in the estimated glomerular filtration rate in both male and female individuals. We did not identify a significant correlation between the estimated glomerular filtration rate and either the percentage of CD4, CD8, and B cells or CD4/CD8 ratio. The median percentage of CD8+ T cells was significantly lower in individuals with an estimated glomerular filtration rate >60 mL/min/1.73 m². CONCLUSIONS: In this study, no statistical correlation was found between the estimated glomerular filtration rate and either the lymphocyte phenotype (CD4+,CD8+, and CD19+ cells) or the CD4/CD8 ratio in blood.en
dc.description.affiliationFederal University of São Paulo
dc.description.affiliationUniversity of São Paulo Epidemiology Department
dc.description.affiliationUnifespUNIFESP, EPM, São Paulo, Brazil
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent39-44
dc.identifierhttp://dx.doi.org/10.6061/clinics/2013(01)OA06
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 68, n. 1, p. 39-44, 2013.
dc.identifier.doi10.6061/clinics/2013(01)OA06
dc.identifier.fileS1807-59322013000100007.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322013000100007
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7588
dc.identifier.wosWOS:000314990200007
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRenal Functionen
dc.subjectElderlyen
dc.subjectImmune Systemen
dc.subjectFlow Cytometryen
dc.titleEvaluation of renal function and immune system cells in elderly individuals from São Paulo Cityen
dc.typeinfo:eu-repo/semantics/article
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