Methimazole-induced hypothyroidism inhibits the panic-like behaviors produced by electrical stimulation of dorsal periaqueductal gray matter of rats

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dc.contributor.authorSiqueira, Carla Coelho
dc.contributor.authorRossoni, Renzo Roldi
dc.contributor.authorCarleti Pereira Tiengo, Ana Neide
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSchenberg, Luiz Carlos
dc.contributor.institutionUniv Fed Espirito Santo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:45Z
dc.date.available2016-01-24T13:59:45Z
dc.date.issued2010-06-01
dc.description.abstractConflicting clinical data on the relationship of panic disorder and thyroid diseases illustrate the need for a simpler approach using animal models. Defensive behaviors evoked by electrical or chemical stimulation of dorsal periaqueductal gray matter (DPAG) have been proposed as a model of panic attack. Therefore, the present study examined the effects of the anti-thyroid agent methimazole (MTZ) either on the panic-like behaviors induced by electrical stimulation of DPAG or the anxiety-like behaviors of rats exposed to the elevated plus-maze (EPM). Male Wistar rats bearing electrodes in the DPAG were stimulated with stepwise increased currents. Rats which displayed galloping at intensities below 60 mu A were retested following 5- and 10-day treatments with MTZ (0.6 mg/kg/day, i.p.) or 10- and 15-day washout periods. MTZ effects on EPM performance were assessed in separate groups. MTZ-treated groups were compared to saline-treated controls. in other experiments, rats were similarly treated with MTZ and the blood was collected for hormone assays. the 10-day treatment with MU produced marked increases in the thresholds of exophthalmus (65%), immobility (75%), trotting (63%), galloping (56%), jumping (47%), defecation (114%) and micturition (85%). Effects outlasted the drug discontinuation. in contrast, MU had variable effects in the EPM, significantly increasing the open-arm exploration in 5-day treated and 10-day washout groups. Biochemical data revealed a small but significant decrease (13%) in free thyroxine in MTZ-treated groups. Although not significant, thyrotrophin levels showed a 111% increase following the 10-day treatment with MU. Selective attenuation by MU of DPAG-evoked defensive behaviors supports attenuation of panic attacks in hypothyroidism. (c) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Espirito Santo, CCS, Dept Ciencias Fisiol, BR-29043125 Vitoria, ES, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFederal University of São Paulo (UNIFESP)
dc.description.sponsorshipIDCNPq: 307074/2003-0
dc.format.extent706-716
dc.identifierhttp://dx.doi.org/10.1016/j.psyneuen.2009.10.011
dc.identifier.citationPsychoneuroendocrinology. Oxford: Pergamon-Elsevier B.V., v. 35, n. 5, p. 706-716, 2010.
dc.identifier.doi10.1016/j.psyneuen.2009.10.011
dc.identifier.issn0306-4530
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32598
dc.identifier.wosWOS:000278431500008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPsychoneuroendocrinology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectThyroiden
dc.subjectPAGen
dc.subjectDefensive behaviorsen
dc.subjectElevated plus-mazeen
dc.subjectAnxietyen
dc.subjectPanicen
dc.titleMethimazole-induced hypothyroidism inhibits the panic-like behaviors produced by electrical stimulation of dorsal periaqueductal gray matter of ratsen
dc.typeinfo:eu-repo/semantics/article
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