Albuminuria, renal function and blood pressure in undernourished children and recovered from undernutrition

Página do item simplificado
dc.contributor.authorMartins, Vinicius J. B.
dc.contributor.authorSesso, Ricardo [UNIFESP]
dc.contributor.authorClemente, Ana P. G.
dc.contributor.authorFernandes, Mariana B. F. [UNIFESP]
dc.contributor.authorSawaya, Ana L. [UNIFESP]
dc.date.accessioned2019-08-19T11:48:43Z
dc.date.available2019-08-19T11:48:43Z
dc.date.issued2017
dc.description.abstractBackground The objective of this study was to investigate some biomarkers of renal function and blood pressure in children who had recovered from undernutrition. Methods This was cross-sectional, comparative study in which a convenience sample of children of both genders (n = 126en
dc.description.abstractage range 6-16 years) treated at the Centre for Nutritional Recovery and Education (Sao Paulo, Brazil) was used. These children were classified into four groups for analysis: (1) children who were well nourished (control groupen
dc.description.abstractn = 50), (2) those showing stunted growth (stunted groupen
dc.description.abstractn = 22), (3) those who were underweight (underweight groupen
dc.description.abstractn = 23) and (4) those who had recovered from undernutrition (recovered groupen
dc.description.abstractn = 31). Results No between-group differences were found for mean levels of albuminuria, serum creatinine and cystatin C, and similar mean estimates of glomerular filtration rate (eGFRen
dc.description.abstractusing either creatinine, cystatin C or both). Almost 14% of the stunted group, 4% of the underweight group and 3% of the recovered group had albuminuria of >30 mg/g creatinine chi-square p = 0.034)en
dc.description.abstractnone of the control children showed albuminuria of >30 mg/g creatinine. Mean systolic (SBP) and diastolic blood pressure (DBP) adjusted for age and gender of the children in the stunted [ SBP (95% confidence interval): 92 (88-96) mmHgen
dc.description.abstractDBP: 47 (44-49) mmHg] and recovered [ SBP: 93 (90-96) mmHgen
dc.description.abstractDBP: 49 (47-51) mmHg] groups were significantly lower than those of the controls [ SBP: 98 (95-100) mmHg, P = 0.027en
dc.description.abstractDBP: 53 (5255) mmHg, P = 0.001]. After additional adjustment for height, mean DBP remained significantly lower in the recovered group compared with the control group [ 49 (46-51) vs. 53 (51-55) mmHg, respectivelyen
dc.description.abstractP = 0.018). Logistic regression analysis showed that the stunted group had a 8.4-fold higher chance of developing albuminuria (>10 mg/g creatinine) than the control children (P = 0.006). Conclusions No alterations in renal function were found in underweight children and those who had recovered from undernutrition, whereas children with stunted growth presented with a greater risk for albuminuria. A lower DBP was found in children with stunted growth and those who had recovered from undernutrition.en
dc.description.affiliationUniv Fed Paraiba, Dept Physiol & Pathol, Ctr Ciencias Saude, Campus 1,Cidade Univ, BR-58051900 Joao Pessoa, PB, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Med, Rua Botucatu 740, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliationUniv Fed Alagoas, Nutr Coll, Campus AC Simoes,Ave Lourival Melo Mota S-N, BR-57072900 Maceio, AL, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Physiol, 862 Edificio Ciencias Biomed,2 Andar, BR-04023060 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Dept Med, Rua Botucatu 740, BR-04023900 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, Dept Physiol, 862 Edificio Ciencias Biomed,2 Andar, BR-04023060 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Fundação de Amparo a Pesquisa do Estado de São Paulo, Brazil)
dc.description.sponsorshipCAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior)
dc.description.sponsorshipCNPQ (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
dc.description.sponsorshipIDFAPESP: 2010/51237-2
dc.description.sponsorshipIDCNPq: 302740/2010-4
dc.format.extent1555-1563
dc.identifierhttp://dx.doi.org/10.1007/s00467-017-3602-y
dc.identifier.citationPediatric Nephrology. New York, v. 32, n. 9, p. 1555-1563, 2017.
dc.identifier.doi10.1007/s00467-017-3602-y
dc.identifier.issn0931-041X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51333
dc.identifier.wosWOS:000408418900011
dc.language.isoeng
dc.publisherSpringer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectRenal functionen
dc.subjectBlood pressureen
dc.subjectUndernutritionen
dc.subjectStuntingen
dc.subjectUnderweighten
dc.subjectNutritional recoveryen
dc.titleAlbuminuria, renal function and blood pressure in undernourished children and recovered from undernutritionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos