Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection

Página do item simplificado
dc.contributor.authorMendoza Lopez, Rossana Veronica
dc.contributor.authorLevi, Jose Eduardo
dc.contributor.authorEluf-Neto, Jose
dc.contributor.authorKoifman, Rosalina Jorge
dc.contributor.authorKoifman, Sergio
dc.contributor.authorCurado, Maria Paula
dc.contributor.authorMichaluart-Junior, Pedro
dc.contributor.authorAlves Figueiredo, David Livingstone
dc.contributor.authorSaggioro, Fabiano Pinto
dc.contributor.authorCarvalho, Marcos Brasilino de
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.authorAbrahão, Marcio [UNIFESP]
dc.contributor.authorGois-Filho, Francisco de
dc.contributor.authorTajara, Eloiza Helena
dc.contributor.authorWaterboer, Tim
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorBrennan, Paul
dc.contributor.authorWuensch-Filho, Victor
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHosp Canc Barretos
dc.contributor.institutionFundacao Oswaldo Cruz
dc.contributor.institutionHosp Araujo Jorge
dc.contributor.institutionInt Prevent Res Inst
dc.contributor.institutionHosp Heliopolis
dc.contributor.institutionHosp Canc AC Camargo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Canc Arnaldo Viera Carvalho
dc.contributor.institutionFac Med Sao Jose Rio Preto
dc.contributor.institutionGerman Canc Res Ctr
dc.contributor.institutionMt Sinai Sch Med
dc.contributor.institutionInt Agcy Res Canc
dc.date.accessioned2016-01-24T14:35:30Z
dc.date.available2016-01-24T14:35:30Z
dc.date.issued2014-04-01
dc.description.abstractThe role of human papillomavirus (HPV) on head and neck squamous cell carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated the HPV16 infection on survival of HNSCC Brazilian patient series.This cohort comprised 1,093 HNSCC cases recruited from 1998 to 2008 in four Brazilian cities and followed up until June 2009. HPV16 antibodies were analyzed by multiplex Luminex assay. in a subset of 398 fresh frozen or paraffin blocks of HNSCC specimens, we analyzed for HPV16 DNA by L1 generic primer polymerase chain reaction. HNSCC survival according to HPV16 antibodies was evaluated through Kaplan-Meier method and Cox regression.Prevalence of HPV16 E6 and E6/E7 antibodies was higher in oropharyngeal cancer than in other head and neck tumor sites. HPV16 DNA positive in tumor tissue was also higher in the oropharynx. Seropositivity for HPV16 E6 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer. the presence of HPV16 E6/E7 antibodies was correlated with improved HNSCC survival and oropharyngeal cancer survival. the death risk of oropharyngeal squamous cell carcinoma patients HPV16 E6/E7 antibodies positive was 78 % lower than to those who test negative.Oropharyngeal squamous cell carcinoma is less aggressive in the HPV16 E6/E7 positive serology patients. HPV16 E6/E7 antibody is a clinically sensible surrogate prognostic marker of oropharyngeal squamous cell carcinoma.en
dc.description.affiliationUniv São Paulo, Fac Saude Publ, BR-01246904 São Paulo, Brazil
dc.description.affiliationHosp Canc Barretos, Inst Ensino & Pesquisa, Barretos, Brazil
dc.description.affiliationUniv São Paulo, Inst Med Trop, BR-01246904 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, BR-01246904 São Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio de Janeiro, Brazil
dc.description.affiliationHosp Araujo Jorge, Goiania, Brazil
dc.description.affiliationInt Prevent Res Inst, Lyon, France
dc.description.affiliationUniv São Paulo, Fac Med, Hosp Clin, BR-01246904 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Hosp Clin, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationHosp Heliopolis, São Paulo, Brazil
dc.description.affiliationHosp Canc AC Camargo, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Hosp São Paulo, São Paulo, Brazil
dc.description.affiliationInst Canc Arnaldo Viera Carvalho, São Paulo, Brazil
dc.description.affiliationFac Med Sao Jose Rio Preto, São Paulo, Brazil
dc.description.affiliationGerman Canc Res Ctr, Heidelberg, Germany
dc.description.affiliationMt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
dc.description.affiliationInt Agcy Res Canc, F-69372 Lyon, France
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipIDFAPESP: 10/50733-6
dc.description.sponsorshipIDFAPESP: 09/52031-1
dc.description.sponsorshipIDFAPESP: 04/12054-9
dc.description.sponsorshipIDEuropean Commission: IC18-CT97-0222
dc.format.extent461-471
dc.identifierhttp://dx.doi.org/10.1007/s10552-014-0348-8
dc.identifier.citationCancer Causes & Control. Dordrecht: Springer, v. 25, n. 4, p. 461-471, 2014.
dc.identifier.doi10.1007/s10552-014-0348-8
dc.identifier.issn0957-5243
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37595
dc.identifier.wosWOS:000332647500006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCancer Causes & Control
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectHuman papillomavirusen
dc.subjectSerologyen
dc.subjectPrognosisen
dc.subjectHead and neck canceren
dc.subjectPrevalenceen
dc.titleHuman papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infectionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos