Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Andersen, Monica L. [UNIFESP]; Alvarenga, Tathiana A. [UNIFESP]; Mazzotti, Diego R. [UNIFESP]; Guindalini, Camila [UNIFESP]; Pellegrino, Renata [UNIFESP]; Barrueco, Karina F. [UNIFESP]; Santos-Silva, Rogerio [UNIFESP]; Bittencourt, Lia R. [UNIFESP]; Tufik, Sergio [UNIFESP]

Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Data

2011-02-01

Autores

Andersen, Monica L.

Alvarenga, Tathiana A.

Mazzotti, Diego R.

Guindalini, Camila

Pellegrino, Renata

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Tipo

Artigo

Resumo

Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in São Paulo, Brazil.Design: Population-based questionnaire study.Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute.Patient(s): the total study participants included 467 men.Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping.Main Outcome Measure(s): the effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample.Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62).Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. the results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.)

Citação

Fertility and Sterility. New York: Elsevier B.V., v. 95, n. 2, p. 621-624, 2011.