Cerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertension

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dc.citation.volume233
dc.contributor.authorTreptow, Erika [UNIFESP]
dc.contributor.authorOliveira, Mayron Faria [UNIFESP]
dc.contributor.authorSoares, Aline [UNIFESP]
dc.contributor.authorRamos, Roberta Pulcheri [UNIFESP]
dc.contributor.authorMedina, Luiz [UNIFESP]
dc.contributor.authorLima, Rita [UNIFESP]
dc.contributor.authorAlencar, Maria Clara [UNIFESP]
dc.contributor.authorFerreira, Eloara Vieira [UNIFESP]
dc.contributor.authorOta-Arakaki, Jaquelina Sonoe [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorNery, Luiz Eduardo [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-31T12:47:30Z
dc.date.available2020-07-31T12:47:30Z
dc.date.issued2016
dc.description.abstractHypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls. Cerebral BFI was lower in patients than controls at similar transcutaneous PCO2 (PtcCO(2)) levels in both testing conditions. In fact, while BFI increased from hypocapnia to hypercapnia in all controls, it failed to increase in 17/25 (68%) patients. Thus, BFI increased to a lesser extent from hypo to hypercapnia ("Delta") in patients, i.e., they showed lower Delta BFI/Delta PtcCO(2) ratios than controls. In conclusion, CBFmicr and CVRCO2 are lessened in clinically stable, mildly-impaired patients with PAH. These abnormalities might be associated with relevant clinical outcomes (hyperventilation and dyspnea, cognition, cerebrovascular disease) being potentially amenable to pharmacological treatment. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Paulista Sch Med UNIFESP EPM, Div Resp,Dept Med, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Div Resp Dis, Dept Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationQueens Univ, Div Resp & Crit Care Med, Dept Med, Lab Clin Exercise Physiol LACEP, Kingston, ON, Canada
dc.description.affiliationUnifespPulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Respiratory Division, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), Paulista School of Medicine (UNIFESP-EPM), Brazil
dc.description.affiliationUnifespDivision of Respiratory Diseases, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.affiliationUnifespDepartamento de Psicobiologia da Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 11/52102-6
dc.format.extent60-65
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2016.08.001
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam, v. 233, p. 60-65, 2016.
dc.identifier.doi10.1016/j.resp.2016.08.001
dc.identifier.issn1569-9048
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56868
dc.identifier.wosWOS:000386410600009
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCerebral blood flowen
dc.subjectCarbon dioxideen
dc.subjectPulmonary hypertensionen
dc.subjectVentilationen
dc.subjectNear-infrared spectroscopyen
dc.titleCerebral microvascular blood flow and CO2 reactivity in pulmonary arterial hypertensionen
dc.typeinfo:eu-repo/semantics/article
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