Behavioural changes observed in demyelination model shares similarities with white matter abnormalities in humans

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dc.contributor.authorOliveira, Nathalia Serra de [UNIFESP]
dc.contributor.authorBoilesen, Sabine Nunes [UNIFESP]
dc.contributor.authorCarvalho, Carolina Prado de França [UNIFESP]
dc.contributor.authorLe Sueur-Maluf, Luciana [UNIFESP]
dc.contributor.authorZollner, Ricardo de Lima
dc.contributor.authorSpadari, Regina Celia [UNIFESP]
dc.contributor.authorMedalha, Carla Christina [UNIFESP]
dc.contributor.authorCastro, Glaucia Monteiro de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2016-01-24T14:40:35Z
dc.date.available2016-01-24T14:40:35Z
dc.date.issued2015-07-01
dc.description.abstractMultiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Further to the symptoms resulting from demyelination, new studies point to the involvement of neuroinflammation and white matter abnormalities in psychiatric disorders and neurodegenerative diseases. Cuprizone, a model of MS, produces consistent demyelination and elicits behavioural, morphological and inflammatory changes in animals that share some similarities with those observed in humans. in this study, we used the cuprizone model in Lewis rats to evaluate clinical signs triggered by the demyelination process which could be comparable with the symptoms seen in white matter abnormalities in human beings. To induce the demyelination process, 0.6% cuprizone was added to the Lewis rats' diet for 4 weeks. We proceeded with behavioural, morphological and immunological analyses. Animals fed with cuprizone exhibited behavioural changes: higher scores in the neurotoxicity test, reduced exploratory and locomotion behaviour, and also an increase of permanency in the closed arm of the elevated plus maze test, were observed. in these analyses, the animals showed motor coordination impairment and anxiety-like behaviour. Demyelination also triggered changes in discrimination of objects identified by an increase in the time spent close to a familiar object. These behavioural alterations were associated with a significant increase in the levels of TNF-alpha and corticosterone, consistent with the activation of microglia and astrocytes. Taken together, the results of this work show the cuprizone/Lewis rat model demyelination as an attractive paradigm for studying the correlation between white matter abnormalities and behaviour. (C) 2015 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Programa Interdisciplinar Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, FCM, LIAE, BR-13083887 Campinas, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Programa Interdisciplinar Ciencias Saude, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Biociencias, BR-11015020 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 07/07828-3
dc.format.extent265-275
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2015.03.038
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 287, p. 265-275, 2015.
dc.identifier.doi10.1016/j.bbr.2015.03.038
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/39148
dc.identifier.wosWOS:000355037700034
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttps://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBehaviouren
dc.subjectCognitionen
dc.subjectCuprizoneen
dc.subjectNeuroinflammationen
dc.subjectWhite matteren
dc.titleBehavioural changes observed in demyelination model shares similarities with white matter abnormalities in humansen
dc.typeinfo:eu-repo/semantics/article
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