SKELETAL-MUSCLE INVOLVEMENT in TROPICAL SPASTIC PARAPARESIS HTLV-1-ASSOCIATED MYELOPATHY

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dc.contributor.authorGabbai, Alberto Alain [UNIFESP]
dc.contributor.authorWiley, C. A.
dc.contributor.authorOliveira, ASB
dc.contributor.authorSmith, R.
dc.contributor.authorSchmidt, B.
dc.contributor.authorNobrega, JAM
dc.contributor.authorBordin, J. O.
dc.contributor.authorRoman, G. C.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNIV CALIF SAN DIEGO
dc.contributor.institutionNINCDS
dc.date.accessioned2016-01-24T11:40:19Z
dc.date.available2016-01-24T11:40:19Z
dc.date.issued1994-08-01
dc.description.abstractThe frequency of muscle involvement in TSP/HAM is not known, nor is the precise role that HTLV-1 and the diverse cytokines play in the genesis of HTLV-1-associated diseases. in order to better define the frequency and characteristics of the skeletal muscle involvement in TSP/ HAM, we studied 11 affected patients. EMG was performed in 9 patients and muscle biopsy was performed in all 11. Muscle tissue was analyzed using: reverse transcriptase PCR for interleukin-1 in 8; PCR for HTLV-1 proviral DNA in 5; and electron microscopy for viral particles in 3. We found pathologic alterations in all 11 patients. Four patients (36%) had a neurogenic process, while a primary muscle involvement was observed in the rest (64%). Four patients (36%) had polymyositis, and 3 (27%) had a noninflammatory myopathy. Muscle weakness in the upper limbs was significantly associated with inflammation in the muscle biopsy. EMG was abnormal in only 2 of 9 patients. Reverse transcriptase PCR did not demonstrate message for interleukin-1 in any sample examined. PCR did identify HTLV-1 proviral DNA in the muscle of 3 patients. Retroviral-like particles were found, by EM, in only one biopsy. HTLV-1 may play an important role in the pathogenesis of the frequent myopathies associated with HAM/TSP. (C) 1994 John Wiley & Sons, Inc.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT NEUROL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT ANAT,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT PATHOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT HEMATOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUNIV CALIF SAN DIEGO,DEPT PATHOL,SAN DIEGO,CA 92103
dc.description.affiliationNINCDS,NEUROEPIDEMIOL BRANCH,BETHESDA,MD 20892
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT NEUROL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT ANAT,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT PATHOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT HEMATOL,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent923-930
dc.identifierhttp://dx.doi.org/10.1002/mus.880170812
dc.identifier.citationMuscle & Nerve. New York: John Wiley & Sons Inc, v. 17, n. 8, p. 923-930, 1994.
dc.identifier.doi10.1002/mus.880170812
dc.identifier.issn0148-639X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25421
dc.identifier.wosWOS:A1994NY96600011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMuscle & Nerve
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectTSP/HAMen
dc.subjectHTLV-1en
dc.subjectPOLYMYOSITISen
dc.subjectPCR ELECTRON MICROSCOPYen
dc.subjectMYOPATHYen
dc.titleSKELETAL-MUSCLE INVOLVEMENT in TROPICAL SPASTIC PARAPARESIS HTLV-1-ASSOCIATED MYELOPATHYen
dc.typeinfo:eu-repo/semantics/article
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