Expression Profiling of Cell Cycle Regulatory Proteins in Oropharyngeal Carcinomas Using Tissue Microarrays

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dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorNascimento, Fábio Dupart [UNIFESP]
dc.contributor.authorFracalossi, Ana Carolina Cuzzuol [UNIFESP]
dc.contributor.authorGomes, Thiago Simao [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorFranco, Marcello Fabiano de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:38:31Z
dc.date.available2018-06-15T17:38:31Z
dc.date.issued2010-05-01
dc.description.abstractAim: The aim of this study was to investigate the expressions of cell cycle regulatory proteins such as p53, p16, p21, and Rb in squamous cell carcinoma of the oropharynx and their relation to histological differentiation, staging of disease, and prognosis. Patients and Methods: Paraffin blocks from 21 primary tumors were obtained from archives of the Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM. Immunohistochemistry was used to detect the expression of p53, p16, p21, and Rb by means of tissue microarrays. Results: Expression of p53, p21, p16 and Rb was not correlated with the stage of disease, histopathological grading or recurrence in squamous cell carcinoma of the oropharynx. Conclusion: Taken together, our results suggest that p53, p16, p21 and Rb are not reliable biomarkers for prognosis of the tumor severity or recurrence in squamous cell carcinoma of the oropharynx as depicted by tissue microarrays and immunohistochemistry.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Patol, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Patol, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 07/01228-4
dc.format.extent315-320
dc.identifierhttp://iv.iiarjournals.org/content/24/3/315.full
dc.identifier.citationIn Vivo. Athens: Int Inst Anticancer Research, v. 24, n. 3, p. 315-320, 2010.
dc.identifier.issn0258-851X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43915
dc.identifier.wosWOS:000279035400011
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSquamous cell carcinomasen
dc.subjecttissue microarrayen
dc.subjectimmunohistochemistryen
dc.subjectp53en
dc.subjectp16en
dc.subjectp21en
dc.subjectRben
dc.titleExpression Profiling of Cell Cycle Regulatory Proteins in Oropharyngeal Carcinomas Using Tissue Microarraysen
dc.typeinfo:eu-repo/semantics/article
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