Transfer of IgG subclasses across placenta in term and preterm newborns

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dc.contributor.authorCosta Carvalho, B. T.
dc.contributor.authorVieira, H. M.
dc.contributor.authorDimantas, RBR
dc.contributor.authorArslanian, C.
dc.contributor.authorNaspitz, Charles Kirov [UNIFESP]
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.contributor.authorCarneiroSampaio, MMS
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:23:59Z
dc.date.available2018-06-15T16:23:59Z
dc.date.issued1996-02-01
dc.description.abstractIn order to study placental transfer of IgG subclasses, paired blood samples were collected from mothers and umbilical cord of preterm (N = 69) and full-term (N = 68) newborns. The full-term group was further divided into 3 subgroups: appropriate for gestational age (AGA, N = 43), large for gestational age (LGA, N = 13) and small for gestational age (SGA, N = 12), according to birth weight. IgC subclasses (IgG1, IgG2, IgG3 and IgG4) were measured by the single radial immunodiffusion technique using monoclonal antibodies. IgG1 and IgG3 newborn subclass concentrations (10.17 and 0.57 g/l, respectively) increased with increasing gestational age and reached maternal levels (IgG1 = 8.86; IgG3 = 0.67 g/l) during the 37th week of pregnancy. Low levels of these subclasses were found in premature newborns. IgG2 from newborns were always lower than maternal levels (P<0.05). LGA and SGA newborns had equivalent levels of IgG1 and IgG2 compared with AGA. SGA newborns had higher levels of lgG3 and lower levels of IgG4 than LGA and AGA newborns.en
dc.description.affiliationUNIV SAO PAULO,INST CIENCIAS BIOMED 3,DEPT IMUNOL,BR-05508900 SAO PAULO,BRAZIL
dc.description.affiliationUNIV SAO PAULO,ESCOLA PAULISTA MED,DEPT PEDIAT,BR-04025002 SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIV SAO PAULO,ESCOLA PAULISTA MED,DEPT PEDIAT,BR-04025002 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent201-204
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 2, p. 201-204, 1996.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43104
dc.identifier.wosWOS:A1996TV30300005
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectpreterm newbornen
dc.subjectpassive immunityen
dc.subjectplacentaen
dc.subjectimmunoglobulinen
dc.subjectIgGen
dc.titleTransfer of IgG subclasses across placenta in term and preterm newbornsen
dc.typeinfo:eu-repo/semantics/article
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