Biomarkers of Spontaneous Preterm Birth: An Overview of the Literature in the Last Four Decades

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dc.contributor.authorMenon, Ramkumar
dc.contributor.authorTorloni, Maria Regina [UNIFESP]
dc.contributor.authorVoltolini, Chiara
dc.contributor.authorTorricelli, Michela
dc.contributor.authorMerialdi, Mario
dc.contributor.authorBetran, Ana Pilar
dc.contributor.authorWidmer, Mariana
dc.contributor.authorAllen, Tomas
dc.contributor.authorDavydova, Iulia
dc.contributor.authorKhodjaeva, Zulfiya
dc.contributor.authorThorsen, Poul
dc.contributor.authorKacerovsky, Marian
dc.contributor.authorTambor, Vojtich
dc.contributor.authorMassinen, Tytti
dc.contributor.authorNace, Judith
dc.contributor.authorArora, Chander
dc.contributor.institutionUniv Texas Med Branch
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Siena
dc.contributor.institutionWHO
dc.contributor.institutionFed Res Ctr Obstet & Gynecol & Perinatol
dc.contributor.institutionLillebaelt Hosp
dc.contributor.institutionHradec Kralove Charles Univ
dc.contributor.institutionPerkin Elmer Corp
dc.contributor.institutionUniv Tubingen
dc.contributor.institutionCedars Sinai Med Ctr
dc.date.accessioned2016-01-24T14:17:26Z
dc.date.available2016-01-24T14:17:26Z
dc.date.issued2011-11-01
dc.description.abstractBackground: Understanding spontaneous preterm birth ([PTB] < 37 weeks) is difficult due to heterogeneities associated with multitudes of risk factors and pathophysiological pathways. Several biomarkers are routinely used clinically for predicting preterm labor; however, these factors are either nonspecific or detected too late. Objective: Systematic review of literature on PTB biomarkers in the last 40 years to map out the existing knowledge and gaps in understanding PTB biomarkers. Search strategies: Five electronic databases were searched for human studies on PTB biomarkers published in any language between 1965 and 2008. Selection criteria: the phenotype of interest for final data extraction was exclusively spontaneous PTB with no rupture of membranes. Data extraction included (a) general characteristics of the study (clinical setting, period, and study design), (b) study/participant characteristics (inclusion and exclusion criteria, race/ethnicity, number of participants, gestational age at sampling, (c) characteristics of the biomarker (type, rationale for its selection, type of biological sample, and assay used, and (d) concentration of biomarkers in cases and controls. Data collection and analysis: the search yielded 7255 citations and data were extracted from 217 articles which met our inclusion and exclusion criteria. Main results: A total of 116 different biomarkers were reported and these were assayed 578 times in the 217 included studies. Over two thirds of the 217 studies were performed on North American or European populations. No reliable biomarkers emerged as a risk predictor of PTB. Conclusions: Identifying similar studies on biomarkers for the prediction of PTB was a very challenging task due heterogeneities in study design, sampling issues (types, timing and processing), assay methods, and analyses. Major areas of concern identified in this review include poor phenotype definition, nonideal study designs and poor rationale for biomarker selection and assays and population stratification issues.en
dc.description.affiliationUniv Texas Med Branch, Div Maternal Fetal Med, Dept OB & GYN, Galveston, TX USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUniv Siena, Dept Obstet & Gynecol, I-53100 Siena, Italy
dc.description.affiliationWHO, WHO Lib, CH-1211 Geneva, Switzerland
dc.description.affiliationFed Res Ctr Obstet & Gynecol & Perinatol, Moscow, Russia
dc.description.affiliationLillebaelt Hosp, Dept Gynecol & Obstet, Kolding, Denmark
dc.description.affiliationHradec Kralove Charles Univ, Dept Obstet & Gynaecol, Hradec Kralove, Czech Republic
dc.description.affiliationPerkin Elmer Corp, Turku, Finland
dc.description.affiliationUniv Tubingen, Dept Obstet & Gynecol, Tubingen, Germany
dc.description.affiliationCedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipPREBIC, Inc.
dc.format.extent1046-1070
dc.identifierhttp://dx.doi.org/10.1177/1933719111415548
dc.identifier.citationReproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 18, n. 11, p. 1046-1070, 2011.
dc.identifier.doi10.1177/1933719111415548
dc.identifier.issn1933-7191
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34218
dc.identifier.wosWOS:000296206300002
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofReproductive Sciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectprematurityen
dc.subjectrisk factorsen
dc.subjectpreventionen
dc.subjectinterventionen
dc.subjectcytokinesen
dc.subjectpathwaysen
dc.titleBiomarkers of Spontaneous Preterm Birth: An Overview of the Literature in the Last Four Decadesen
dc.typeinfo:eu-repo/semantics/article
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